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Sytl1 Gene Detail
Summary
  • Symbol
    Sytl1
  • Name
    synaptotagmin-like 1
  • Synonyms
    MGC:7008, PSGL-1, Slp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933365
    NCBI Gene: 269589
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132980401-132990398 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933365
 protein coding gene Chr4:132980401-132990424 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028890
 protein coding gene Chr4:135487652-135498984 (-)
A/J MGP_AJ_G0028849
 protein coding gene Chr4:129822759-129832803 (-)
AKR/J MGP_AKRJ_G0028802
 protein coding gene Chr4:133505176-133515220 (-)
BALB/cJ MGP_BALBcJ_G0028872
 protein coding gene Chr4:130443697-130453752 (-)
C3H/HeJ MGP_C3HHeJ_G0028586
 protein coding gene Chr4:133756789-133766833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029314
 protein coding gene Chr4:140358903-140368926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026585
 protein coding gene Chr4:122903670-122913242 (-)
CAST/EiJ MGP_CASTEiJ_G0028019
 protein coding gene Chr4:131865779-131875786 (-)
CBA/J MGP_CBAJ_G0028552
 protein coding gene Chr4:144013480-144023524 (-)
DBA/2J MGP_DBA2J_G0028701
 protein coding gene Chr4:130243144-130253214 (-)
FVB/NJ MGP_FVBNJ_G0028668
 protein coding gene Chr4:129115905-129128086 (-)
LP/J MGP_LPJ_G0028802
 protein coding gene Chr4:135617125-135627192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028694
 protein coding gene Chr4:148540134-148550189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029352
 protein coding gene Chr4:133924677-133934700 (-)
PWK/PhJ MGP_PWKPhJ_G0027740
 protein coding gene Chr4:126953439-126963500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027566
 protein coding gene Chr4:129768767-129778853 (-)
WSB/EiJ MGP_WSBEiJ_G0028099
 protein coding gene Chr4:134098536-134108559 (-)



Homology
more
  • Human Ortholog
    SYTL1, synaptotagmin like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYTL1, synaptotagmin like 1
  • Synonyms
    JFC1, SLP1
  • Links
    NCBI Gene ID: 84958
    neXtProt AC: NX_Q8IYJ3
    UniProt: Q8IYJ3

  • Chr Location
    1p36.11; chr1:27342020-27353937 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased number of acinar zygomen granules in a fasted state that can be released by strong stimuli of the fed state.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    12
  • cDNA Data
    51
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269589 NCBI Gene Model | MGI Sequence Detail 9998 C57BL/6J ±  kb
    transcript NM_031393 RefSeq | MGI Sequence Detail 1940 C57BL/6  
    polypeptide Q99N80 UniProt | EBI | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:68115 Fukuda M, et al., Synaptotagmin-like protein 1-3: a novel family of c-terminal-type tandem c2 proteins. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1226-33
    • Latest
      J:276845 Ramadass M, et al., The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. J Leukoc Biol. 2019 Jun;105(6):1209-1224
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory