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Gps2 Gene Detail
Summary
  • Symbol
    Gps2
  • Name
    G protein pathway suppressor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891751
    NCBI Gene: 56310
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69804714-69807417 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891751
 protein coding gene Chr11:69804714-69807882 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018568
 protein coding gene Chr11:70400825-70403529 (+)
A/J MGP_AJ_G0018536
 protein coding gene Chr11:67735560-67738263 (+)
AKR/J MGP_AKRJ_G0018505
 protein coding gene Chr11:69757917-69760620 (+)
BALB/cJ MGP_BALBcJ_G0018508
 protein coding gene Chr11:68066909-68069612 (+)
C3H/HeJ MGP_C3HHeJ_G0018321
 protein coding gene Chr11:69794477-69797180 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018959
 protein coding gene Chr11:72526432-72529135 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016604
 protein coding gene Chr11:64662198-64664918 (+)
CAST/EiJ MGP_CASTEiJ_G0017876
 protein coding gene Chr11:70034717-70037424 (+)
CBA/J MGP_CBAJ_G0029386
 protein coding gene Chr5:98078265-98080593 (-)
DBA/2J MGP_DBA2J_G0018403
 protein coding gene Chr11:67321478-67324182 (+)
FVB/NJ MGP_FVBNJ_G0018393
 protein coding gene Chr11:66962753-66965459 (+)
LP/J MGP_LPJ_G0018473
 protein coding gene Chr11:70983588-70986292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018416
 protein coding gene Chr11:76370318-76373021 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019001
 protein coding gene Chr11:70028363-70031066 (+)
PWK/PhJ MGP_PWKPhJ_G0017650
 protein coding gene Chr11:67972209-67975262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017440
 protein coding gene Chr11:69837765-69840471 (+)
WSB/EiJ MGP_WSBEiJ_G0017930
 protein coding gene Chr11:69690891-69693595 (+)



Homology
more
  • Human Ortholog
    GPS2, G protein pathway suppressor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPS2, G protein pathway suppressor 2
  • Synonyms
    AMF-1
  • Links
    NCBI Gene ID: 2874
    neXtProt AC: NX_Q13227
    UniProt: Q13227

  • Chr Location
    17p13.1; chr17:7311324-7315564 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    80
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023170 Ensembl Gene Model | MGI Sequence Detail 2704 C57BL/6J ±  kb
transcript ENSMUST00000072581 Ensembl | MGI Sequence Detail 1311 Not Applicable  
polypeptide ENSMUSP00000072389 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 80

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144211
References
more
  • Summaries
    All 53
    Gene Ontology 13
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:305187 Huang Z, et al., The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages. Mol Cell. 2021 Mar 4;81(5):953-968.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory