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Fbxw7 Gene Detail
Summary
  • Symbol
    Fbxw7
  • Name
    F-box and WD-40 domain protein 7
  • Synonyms
    1110001A17Rik, AGO, Cdc4, Fbw7, Fbxo30, Fbxw6, SEL-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354695
    NCBI Gene: 50754
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:84722575-84886505 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.70 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354695
 protein coding gene Chr3:84721901-84886505 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027347
 protein coding gene Chr3:84782040-84952805 (+)
A/J MGP_AJ_G0027311
 protein coding gene Chr3:81929393-82095004 (+)
AKR/J MGP_AKRJ_G0027277
 protein coding gene Chr3:83871034-84043782 (+)
BALB/cJ MGP_BALBcJ_G0027320
 protein coding gene Chr3:82007223-82171623 (+)
C3H/HeJ MGP_C3HHeJ_G0027064
 protein coding gene Chr3:84182329-84350313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027766
 protein coding gene Chr3:87918639-88093473 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025119
 protein coding gene Chr3:77595038-77755817 (+)
CAST/EiJ MGP_CASTEiJ_G0026511
 protein coding gene Chr3:84372592-84543353 (+)
CBA/J MGP_CBAJ_G0027039
 protein coding gene Chr3:90870153-91059177 (+)
DBA/2J MGP_DBA2J_G0027175
 protein coding gene Chr3:81438130-81606644 (+)
FVB/NJ MGP_FVBNJ_G0027143
 protein coding gene Chr3:79716381-79884690 (+)
LP/J MGP_LPJ_G0027283
 protein coding gene Chr3:85732123-85899662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027162
 protein coding gene Chr3:97185188-97360614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027824
 protein coding gene Chr3:83673493-83848852 (+)
PWK/PhJ MGP_PWKPhJ_G0026245
 protein coding gene Chr3:81225378-81391536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026061
 protein coding gene Chr3:82851590-83021429 (+)
WSB/EiJ MGP_WSBEiJ_G0026589
 protein coding gene Chr3:84040917-84211115 (+)



Homology
more
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW7, F-box and WD repeat domain containing 7
  • Synonyms
    AGO, CDC4, DEDHIL, FBW6, FBW7, FBX30, FBXO30, FBXW6, hAgo, hCdc4, SEL10, SEL-10
  • Links
    NCBI Gene ID: 55294
    neXtProt AC: NX_Q969H0
    UniProt: Q969H0

  • Chr Location
    4q31.3; chr4:152320544-152536092 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FBXW7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    97 phenotypes from 11 alleles in 14 genetic backgrounds
    13 phenotypes from multigenic genotypes
    7 images
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    28
  • cDNA Data
    12
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028086 Ensembl Gene Model | MGI Sequence Detail 163931 C57BL/6J ±  kb
    transcript ENSMUST00000107679 Ensembl | MGI Sequence Detail 4473 Not Applicable  
    polypeptide ENSMUSP00000103306 Ensembl | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 13
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915717
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 17
      Phenotypes 85
    • Earliest
      J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
    • Latest
      J:346081 Cai Z, et al., Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo. Cell Death Dis. 2024 Mar 14;15(3):212
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory