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Ip6k1
Gene Detail
 Symbol
Name
ID
Ip6k1
inositol hexaphosphate kinase 1
MGI:1351633
Synonyms 1200016D08Rik, Ihpk1, InsP6, InsP6k1
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.07 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:108002501-108048780 bp, + strand
From VEGA annotation of GRCm38

  46280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56602  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ip6k1

Human
homologs
Human Homolog IP6K1, inositol hexakisphosphate kinase 1
NCBI Gene ID 9807
neXtProt AC  NX_Q92551
Human Synonyms  IHPK1, PiUS
Human Chr (Location)  3p21.31; chr3:49724295-49786540 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired glucose tolerance, decreased insulin levels, bilateral epididymal aspermia, and testicular degeneration in males.
 
Phenotype Images(1)
Interactions
Ip6k1 interacts with 295 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process inositol metabolic process, inositol phosphate biosynthetic process, ...
Component cytoplasm, nucleolus, ...
Function ATP binding, inositol-1,4,5-trisphosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (102)    Tissues (97)    Images (16)
Theiler Stages: 22
Assay TypeResults
RNA in situ 102
cDNA source data(218)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(218) cDNA(218)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000042012 (Evidence)
Ensembl Gene ModelENSMUSG00000032594 (Evidence)
Entrez Gene27399 (Evidence)
UniGene276155
DFCITC1609875, TC1655812, TC1742934
DoTSDT.101142237, DT.110616421, DT.110616487, DT.535470, DT.91365501, DT.91446469, DT.94233218, DT.94233238, DT.97396692
EC2.7.4.21
Consensus CDS ProjectCCDS23514.1
International Mouse Knockout Project StatusIp6k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042012 VEGA Gene Model | MGI Sequence Detail 46280 C57BL/6J ±  kb
transcript OTTMUST00000110103 VEGA | MGI Sequence Detail 4557 Not Applicable 
polypeptide OTTMUSP00000061354 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005522 Inositol polyphosphate kinase
Protein Ontology PR:000009080 inositol hexakisphosphate kinase 1
References (Earliest) J:58528 Saiardi A, et al., Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol. 1999 Nov 18;9(22):1323-6
(Latest) J:202985 Burton A, et al., Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18970-5
All references(43)
Other
accession IDs
MGI:1914851, MGI:2143219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory