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Gmcl1 Gene Detail
Summary
  • Symbol
    Gmcl1
  • Name
    germ cell-less, spermatogenesis associated 1
  • Synonyms
    2810049L19Rik, Btbd13, Gcl, mglc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345156
    NCBI Gene: 23885
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86668750-86710365 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.75 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    961 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345156
 protein coding gene Chr6:86668750-86710377 (-)
129S1/SvImJ ENSMUSG00200043821
 protein coding gene Chr6:83628754-83670259 (-)
A/J ENSMUSG00195036753
 protein coding gene Chr6:83312887-83354392 (-)
AKR/J ENSMUSG00220026513
 protein coding gene Chr6:82224121-82265764 (-)
BALB/cJ ENSMUSG00180014741
 protein coding gene Chr6:83697347-83738981 (-)
C3H/HeJ ENSMUSG00175034323
 protein coding gene Chr6:93674992-93716497 (+)
C57BL/6NJ ENSMUSG00215017995
 protein coding gene Chr6:83694046-83735665 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028602
 protein coding gene Chr6:82781407-82823280 (-)
CAST/EiJ ENSTCUG00005017183
 protein coding gene Chr6:83639413-83680753 (-)
CBA/J ENSMUSG00210036117
 protein coding gene Chr6:83503943-83545451 (-)
DBA/2J ENSMUSG00185037919
 protein coding gene Chr6:84051120-84092626 (-)
FVB/NJ ENSMUSG00205031813
 protein coding gene Chr6:82681986-82723494 (-)
JF1/MsJ ENSUMUG00000038580
 protein coding gene Chr6:83000687-83042152 (-)
LP/J ENSMUSG00230049531
 protein coding gene Chr6:85185337-85226840 (-)
NOD/ShiLtJ ENSMUSG00190039070
 protein coding gene Chr6:83127734-83169240 (-)
NZO/HlLtJ ENSMUSG00225019524
 protein coding gene Chr6:87150482-87192103 (-)
PWK/PhJ ENSLUMG00010032804
 protein coding gene Chr6:82411609-82459347 (-)
SPRET/EiJ ENSMSPG00010041988
 protein coding gene Chr6:84555869-84597325 (-)
WSB/EiJ ENSIUOG00005027711
 protein coding gene Chr6:84047808-84089406 (-)



Homology
more
  • Human Ortholog
    GMCL1, germ cell-less 1, spermatogenesis associated
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GMCL1, germ cell-less 1, spermatogenesis associated
  • Synonyms
    BTBD13, GCL, GCL1, SPATA29
  • Links
    NCBI Gene ID: 64395
    UniProt: Q96IK5

  • Chr Location
    2p13.3; chr2:69829646-69881384 (+)  GRCh38
  • Human Ortholog
    GMCL2, germ cell-less 2, spermatogenesis associated
  • Synonyms
    GCL, GMCL1L, GMCL1P1
  • Links
    NCBI Gene ID: 64396
    UniProt: Q8NEA9

  • Chr Location
    5q35.3; chr5:178184505-178187371 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired nuclear membrane integrity in liver, endocrine pancreas, and testis. Mutant males show reduced fertility with decreased chromatin condensation and morphologically abnormal sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    23
  • cDNA Data
    65
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001157 Ensembl Gene Model | MGI Sequence Detail 41616 C57BL/6J ±  kb
    transcript ENSMUST00000001185 Ensembl | MGI Sequence Detail 2949 Not Applicable  
    polypeptide ENSMUSP00000001185 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919974
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:57109 Kimura T, et al., Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):223-30
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory