Mcm6 MGI Mouse Gene Detail - MGI:1298227 - minichromosome maintenance complex component 6

Symbol

Mcm6
Name

minichromosome maintenance complex component 6
Synonyms

D1Wsu22e, Mcmd6

Feature Type

protein coding gene
IDs

MGI:1298227
NCBI Gene: 17219
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:128259327-128287401 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 55.80 cM, cytoband E4
Mapping Data

4 experiments

SNPs within 2kb

404 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298227	protein coding gene	Chr1:128259312-128287442 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016429	protein coding gene	Chr1:131572374-131602006 (-)
A/J	MGP_AJ_G0016412	protein coding gene	Chr1:126664482-126695336 (-)
AKR/J	MGP_AKRJ_G0016377	protein coding gene	Chr1:130415113-130443033 (-)
BALB/cJ	MGP_BALBcJ_G0016372	protein coding gene	Chr1:127041346-127071059 (-)
C3H/HeJ	MGP_C3HHeJ_G0016198	protein coding gene	Chr1:130578301-130607332 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016833	protein coding gene	Chr1:136520209-136550619 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014546	protein coding gene	Chr1:120022633-120050741 (-)
CAST/EiJ	MGP_CASTEiJ_G0015779	protein coding gene	Chr1:129563289-129593121 (-)
CBA/J	MGP_CBAJ_G0016171	protein coding gene	Chr1:141125028-141156237 (-)
DBA/2J	MGP_DBA2J_G0016277	protein coding gene	Chr1:125701812-125729864 (-)
FVB/NJ	MGP_FVBNJ_G0016276	protein coding gene	Chr1:124419173-124447301 (-)
LP/J	MGP_LPJ_G0016348	protein coding gene	Chr1:132920078-132950519 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016301	protein coding gene	Chr1:146969234-146997780 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016869	protein coding gene	Chr1:130194421-130223646 (-)
PWK/PhJ	MGP_PWKPhJ_G0015565	protein coding gene	Chr1:124679293-124708185 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015353	protein coding gene	Chr1:129145026-129175443 (-)
WSB/EiJ	MGP_WSBEiJ_G0015841	protein coding gene	Chr1:130152355-130182301 (-)

Human Ortholog

MCM6, minichromosome maintenance complex component 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCM6, minichromosome maintenance complex component 6
Synonyms

MCG40308, Mis5, P105MCM
Links

HGNC:6949

NCBI Gene ID: 4175

neXtProt AC: NX_Q14566

UniProt: Q14566
Chr Location

2q21.3; chr2:135839626-135876443 (-) GRCh38

MGI Vertebrate Homology

Mcm6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCM6
Gene Tree

Mcm6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Gene trapped

11
Radiation induced

1
Genomic Mutations

3 involving Mcm6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.

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All GO Annotations

40
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

38
cDNA Data

228
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcm6, mcm6.2

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All Sequences

87
RefSeq

4
UniProt

5
CCDS

CCDS15252.1, CCDS83586.1

Ensembl

ENSMUSG00000026355 (Evidence)
NCBI Gene

17219

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026355	Ensembl Gene Model \| MGI Sequence Detail	28075	C57BL/6J	± kb
transcript	ENSMUST00000027601	Ensembl \| MGI Sequence Detail	2910	Not Applicable
polypeptide	ENSMUSP00000027601	Ensembl \| MGI Sequence Detail	821	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010248 DNA replication licensing factor MCM6

(term hierarchy)
EC

3.6.4.12
InterPro Domains

IPR008049 DNA replication licensing factor Mcm6

IPR041024 Mcm6, C-terminal winged-helix domain

IPR041562 MCM, AAA-lid domain

IPR001208 MCM domain

IPR027925 MCM, N-terminal domain

IPR033762 MCM OB domain

IPR018525 Mini-chromosome maintenance, conserved site

IPR031327 Mini-chromosome maintenance protein

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 232

Genomic 2

cDNA 229

Primer pair 1

Microarray probesets 5

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MGD-MRK-34267, MGI:106573

Summaries

All 67

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Mcm6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13451	Chr1:128287347-128287435 (-)	10 bp
Tssr13450	Chr1:128287334-128287346 (-)	61 bp
Tssr13449	Chr1:128271204-128271217 (-)	16,190 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23