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Cyp26a1 Gene Detail
Summary
  • Symbol
    Cyp26a1
  • Name
    cytochrome P450, family 26, subfamily a, polypeptide 1
  • Synonyms
    Cyp26, MGC:13860, P450RA, P450RAI, RAH, retinoic acid hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096359
    NCBI Gene: 13082
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37686246-37689984 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.36 cM, cytoband C2-C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096359
 protein coding gene Chr19:37686186-37689984 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025084
 protein coding gene Chr19:36692669-36696390 (+)
A/J MGP_AJ_G0025060
 protein coding gene Chr19:34916447-34920168 (+)
AKR/J MGP_AKRJ_G0025028
 protein coding gene Chr19:36110609-36114331 (+)
BALB/cJ MGP_BALBcJ_G0025058
 protein coding gene Chr19:35003946-35007667 (+)
C3H/HeJ MGP_C3HHeJ_G0024817
 protein coding gene Chr19:36173073-36176794 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025499
 protein coding gene Chr19:37760634-37764354 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022918
 protein coding gene Chr19:34277595-34281324 (+)
CAST/EiJ MGP_CASTEiJ_G0024284
 protein coding gene Chr19:36030461-36034205 (+)
CBA/J MGP_CBAJ_G0024794
 protein coding gene Chr19:39507922-39511643 (+)
DBA/2J MGP_DBA2J_G0024926
 protein coding gene Chr19:34770059-34773780 (+)
FVB/NJ MGP_FVBNJ_G0024887
 protein coding gene Chr19:34577988-34581709 (+)
LP/J MGP_LPJ_G0025012
 protein coding gene Chr19:36795359-36799080 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024918
 protein coding gene Chr19:39314523-39318244 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025557
 protein coding gene Chr19:36191771-36195492 (+)
PWK/PhJ MGP_PWKPhJ_G0024036
 protein coding gene Chr19:34623670-34627583 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023836
 protein coding gene Chr19:35039733-35044978 (+)
WSB/EiJ MGP_WSBEiJ_G0024351
 protein coding gene Chr19:36279739-36283459 (+)



Homology
more
  • Human Ortholog
    CYP26A1, cytochrome P450 family 26 subfamily A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP26A1, cytochrome P450 family 26 subfamily A member 1
  • Synonyms
    CP26, CYP26, P450RAI, P450RAI1
  • Links
    NCBI Gene ID: 1592
    neXtProt AC: NX_O43174
    UniProt: O43174

  • Chr Location
    10q23.33; chr10:93073475-93077885 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die during mid-late gestation and exhibit spina bifida, caudal agenesis, and abnormalities of the kidneys, urogenital tract, hindgut, cervical vertebrae, and rostral hindbrain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1294
  • Tissues
    412
  • cDNA Data
    25
  • Literature Summary
    89
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024987 Ensembl Gene Model | MGI Sequence Detail 3739 C57BL/6J ±  kb
    transcript ENSMUST00000025946 Ensembl | MGI Sequence Detail 1791 Not Applicable  
    polypeptide ENSMUSP00000025946 Ensembl | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 2
      cDNA 28
      Primer pair 16
      Other 15

      Microarray probesets 3
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 89
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:41831 Fujii H, et al., Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 1997 Jul 16;16(14):4163-73
    • Latest
      J:346126 Pappas MP, et al., Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory