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Lasp1 Gene Detail
Summary
  • Symbol
    Lasp1
  • Name
    LIM and SH3 protein 1
  • Synonyms
    Def-4, SH3P6
  • Feature Type
    protein coding gene
  • IDs
    MGI:109656
    NCBI Gene: 16796
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97689826-97729590 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.10 cM, cytoband C-D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109656
 protein coding gene Chr11:97689748-97729591 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019042
 protein coding gene Chr11:100274982-100317937 (+)
A/J MGP_AJ_G0019010
 protein coding gene Chr11:96126879-96167489 (+)
AKR/J MGP_AKRJ_G0018980
 protein coding gene Chr11:99111643-99151755 (+)
BALB/cJ MGP_BALBcJ_G0018983
 protein coding gene Chr11:96627100-96666814 (+)
C3H/HeJ MGP_C3HHeJ_G0018797
 protein coding gene Chr11:99234976-99276825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019436
 protein coding gene Chr11:103364235-103406073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017067
 protein coding gene Chr11:93581397-93621733 (+)
CAST/EiJ MGP_CASTEiJ_G0018351
 protein coding gene Chr11:100100285-100138369 (+)
CBA/J MGP_CBAJ_G0018768
 protein coding gene Chr11:107647703-107690217 (+)
DBA/2J MGP_DBA2J_G0018876
 protein coding gene Chr11:95682449-95722517 (+)
FVB/NJ MGP_FVBNJ_G0018865
 protein coding gene Chr11:95175280-95216525 (+)
LP/J MGP_LPJ_G0018946
 protein coding gene Chr11:100771022-100813074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018892
 protein coding gene Chr11:107462007-107502689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019476
 protein coding gene Chr11:99419586-99460456 (+)
PWK/PhJ MGP_PWKPhJ_G0018123
 protein coding gene Chr11:96665012-96706360 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017913
 protein coding gene Chr11:99135674-99180554 (+)
WSB/EiJ MGP_WSBEiJ_G0018401
 protein coding gene Chr11:99316480-99360033 (+)



Homology
more
  • Human Ortholog
    LASP1, LIM and SH3 protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LASP1, LIM and SH3 protein 1
  • Synonyms
    Lasp-1, MLN50
  • Links
    NCBI Gene ID: 3927
    neXtProt AC: NX_Q14847
    UniProt: Q14847

  • Chr Location
    17q12; chr17:38869859-38921770 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced histamine-stimulated gastric acid secretion and enlarged heart and testes on a mixed background. Mice homozygous for a transgene insertion exhibit abnormal tail vertebrae with scoliosis, transient spina bifida occulta, and a bent tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    96
  • cDNA Data
    18
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038366 Ensembl Gene Model | MGI Sequence Detail 39765 C57BL/6J ±  kb
    transcript ENSMUST00000043843 Ensembl | MGI Sequence Detail 3540 Not Applicable  
    polypeptide ENSMUSP00000042123 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-39655, MGI:2143983, MGI:2429540
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 15
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory