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Fut1 Gene Detail
Summary
  • Symbol
    Fut1
  • Name
    fucosyltransferase 1
  • Synonyms
    H transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109375
    NCBI Gene: 14343
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45266862-45270483 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.39 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109375
 protein coding gene Chr7:45266713-45270483 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032233
 protein coding gene Chr7:45917550-45920795 (+)
A/J MGP_AJ_G0032212
 protein coding gene Chr7:45011752-45015208 (+)
AKR/J MGP_AKRJ_G0032148
 protein coding gene Chr7:46260702-46264169 (+)
BALB/cJ MGP_BALBcJ_G0032224
 protein coding gene Chr7:45005107-45008925 (+)
C3H/HeJ MGP_C3HHeJ_G0031939
 protein coding gene Chr7:46751705-46754952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032716
 protein coding gene Chr7:48171780-48175247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029730
 protein coding gene Chr7:47557236-47560611 (+)
CAST/EiJ MGP_CASTEiJ_G0031268
 protein coding gene Chr7:38189805-38193011 (+)
CBA/J MGP_CBAJ_G0031904
 protein coding gene Chr7:49771705-49778314 (+)
DBA/2J MGP_DBA2J_G0032062
 protein coding gene Chr7:44689854-44693111 (+)
FVB/NJ MGP_FVBNJ_G0032013
 protein coding gene Chr7:44462381-44465828 (+)
LP/J MGP_LPJ_G0032140
 protein coding gene Chr7:46621819-46625074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032050
 protein coding gene Chr7:48459868-48463300 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032732
 protein coding gene Chr7:45470613-45473870 (+)
PWK/PhJ MGP_PWKPhJ_G0030990
 protein coding gene Chr7:38057659-38060860 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030828
 protein coding gene Chr7:33498628-33501912 (+)
WSB/EiJ MGP_WSBEiJ_G0031385
 protein coding gene Chr7:45974851-45978243 (+)



Homology
more
  • Human Ortholog
    FUT1, fucosyltransferase 1 (H blood group)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUT1, fucosyltransferase 1 (H blood group)
  • Synonyms
    H, HH, HSC
  • Links
    NCBI Gene ID: 2523
    neXtProt AC: NX_P19526
    UniProt: P19526

  • Chr Location
    19q13.33; chr19:48748011-48755390 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and healthy, lack alpha(1,2)fucose residues from the apical surface of pancreatic acinar glands and are deficient in epididymal cell surface alpha(1,2)fucosylated glycans but show normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14343 NCBI Gene Model | MGI Sequence Detail 3622 C57BL/6J ±  kb
    transcript NM_008051 RefSeq | MGI Sequence Detail 2580 ZRU/MplStud  
    polypeptide O09160 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 4
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38420
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
    • Latest
      J:343757 Li N, et al., Fucosylation deficiency enhances imiquimod-induced psoriasis-like skin inflammation by promoting CXCL1 expression. Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166988
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory