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Cyp4b1
Gene Detail
Symbol

Name
ID
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
MGI:103225
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:115624725-115647723 bp, - strand
From VEGA annotation of GRCm38

  22999 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 4 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP4B1
Protein SuperFamily: cytochrome P450 CYP4B1
Gene Tree: Cyp4b1

Human
homologs
CYP4B1, cytochrome P450, family 4, subfamily B, polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1580
neXtProt AC: NX_P13584

Human Synonyms: CYPIVB1, P-450HP

Human Chr (Location): 1p33; chr1:46798995-46819349 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Cyp4b1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit resistance to 4-ipomeanol activation and toxicity.
 
Interactions
Cyp4b1 interacts with 70 markers (Mir15b, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 24
cDNA source data(271)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase cyp4b1, cyp4b1.2    NEW 
Molecular
reagents
All nucleic(273) Genomic(1) cDNA(271) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008682 (Evidence)
Ensembl Gene Model ENSMUSG00000028713 (Evidence)
Entrez Gene 13120 (Evidence)
UniGene 1840
NIA Mouse Gene Index U025397
EC 1.14.14.1
Consensus CDS Project CCDS18493.1
International Mouse Phenotyping Consortium Status Cyp4b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008682 VEGA Gene Model | MGI Sequence Detail 22999 C57BL/6J ±  kb
transcript OTTMUST00000019678 VEGA | MGI Sequence Detail 1892 Not Applicable 
polypeptide OTTMUSP00000009017 VEGA | MGI Sequence Detail 511 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)    SNPs within 2kb including multiple locations(125)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR002402 Cytochrome P450, E-class, group II
Protein Ontology PR:000006137 cytochrome P450 4B1
References
(Earliest) J:27761 Imaoka S, et al., Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. Arch Biochem Biophys. 1995 Aug 1;321(1):255-62
(Latest) J:207585 Parkinson OT, et al., Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicol Sci. 2013 Aug;134(2):243-50
All references(32)
Other
accession IDs
MGD-MRK-24096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory