About   Help   FAQ
Cyp4b1
Gene Detail
 Symbol
Name
ID
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
MGI:103225
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:115624725-115647709 bp, - strand
From VEGA annotation of GRCm38

  22985 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 4 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP4B1
Gene Tree: Cyp4b1

Human
homologs
Human Homolog CYP4B1, cytochrome P450, family 4, subfamily B, polypeptide 1
NCBI Gene ID 1580
neXtProt AC  NX_P13584
Human Synonyms  CYPIVB1, P-450HP
Human Chr (Location)  1p33; chr1:46798998-46819349 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit resistance to 4-ipomeanol activation and toxicity.
 
Interactions
Cyp4b1 interacts with 70 markers (Mir15b, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biphenyl metabolic process, cellular aromatic compound metabolic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function aromatase activity, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 24
cDNA source data(271)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(273) Genomic(1) cDNA(271) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008682 (Evidence)
Ensembl Gene ModelENSMUSG00000028713 (Evidence)
Entrez Gene13120 (Evidence)
UniGene1840
NIA Mouse Gene IndexU025397
EC1.14.14.1
Consensus CDS ProjectCCDS18493.1
International Mouse Knockout Project StatusCyp4b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008682 VEGA Gene Model | MGI Sequence Detail 22985 C57BL/6J ±  kb
transcript OTTMUST00000019678 VEGA | MGI Sequence Detail 1878 Not Applicable 
polypeptide OTTMUSP00000009017 VEGA | MGI Sequence Detail 511 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(121 from dbSNP Build 137)    SNPs within 2kb including multiple locations(125)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006137 cytochrome P450 4B1
References (Earliest) J:27761 Imaoka S, et al., Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. Arch Biochem Biophys. 1995 Aug 1;321(1):255-62
(Latest) J:207585 Parkinson OT, et al., Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicol Sci. 2013 Aug;134(2):243-50
All references(31)
Other
accession IDs
MGD-MRK-24096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory