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Rel Gene Detail
Summary
  • Symbol
    Rel
  • Name
    reticuloendotheliosis oncogene
  • Synonyms
    c-Rel
  • Feature Type
    protein coding gene
  • IDs
    MGI:97897
    NCBI Gene: 19696
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:23686847-23720969 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.36 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97897
 protein coding gene Chr11:23686847-23720970 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018092
 protein coding gene Chr11:21512326-21549258 (-)
A/J MGP_AJ_G0018065
 protein coding gene Chr11:20666812-20700891 (-)
AKR/J MGP_AKRJ_G0018029
 protein coding gene Chr11:21403204-21437250 (-)
BALB/cJ MGP_BALBcJ_G0018033
 protein coding gene Chr11:20806817-20846095 (-)
C3H/HeJ MGP_C3HHeJ_G0017847
 protein coding gene Chr11:21287088-21323049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018485
 protein coding gene Chr11:22367386-22402415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016143
 protein coding gene Chr11:19565059-19599562 (-)
CAST/EiJ MGP_CASTEiJ_G0017408
 protein coding gene Chr11:21316084-21356319 (-)
CBA/J MGP_CBAJ_G0017821
 protein coding gene Chr11:23363711-23398091 (-)
DBA/2J MGP_DBA2J_G0017931
 protein coding gene Chr11:20590895-20624996 (-)
FVB/NJ MGP_FVBNJ_G0017923
 protein coding gene Chr11:20372232-20409060 (-)
LP/J MGP_LPJ_G0018002
 protein coding gene Chr11:21599069-21632928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017949
 protein coding gene Chr11:23895015-23931356 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018526
 protein coding gene Chr11:21517670-21551662 (-)
PWK/PhJ MGP_PWKPhJ_G0017189
 protein coding gene Chr11:20641491-20677656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016986
 protein coding gene Chr11:21258600-21292542 (-)
WSB/EiJ MGP_WSBEiJ_G0017462
 protein coding gene Chr11:21150447-21185257 (-)



Homology
more
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REL, REL proto-oncogene, NF-kB subunit
  • Synonyms
    C-Rel, HIVEN86A, IMD92
  • Links
    NCBI Gene ID: 5966
    neXtProt AC: NX_Q04864
    UniProt: Q04864

  • Chr Location
    2p16.1; chr2:60881491-60931612 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human REL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 8 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes defects in lymphocyte proliferation, humoral immunity and cytokine production, and may lead to impaired Th1 responses and resistance to autoimmune disease. Mice lacking only the COOH-terminal region show severehemopoietic defects and lymphoid hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    159
  • cDNA Data
    19
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19696 NCBI Gene Model | MGI Sequence Detail 34123 C57BL/6J ±  kb
    transcript NM_009044 RefSeq | MGI Sequence Detail 7465 ZRU/MplStud  
    polypeptide P15307 UniProt | EBI | MGI Sequence Detail 587 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 20
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13832
    References
    more
    • Summaries
      All 245
      Developmental Gene Expression 13
      Gene Ontology 8
      Phenotypes 132
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:339801 Li T, et al., c-Rel-dependent monocytes are potent immune suppressor cells in cancer. J Leukoc Biol. 2022 Oct;112(4):845-859
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory