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Nedd4
Gene Detail
 Symbol
Name
ID
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297
Synonyms E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:72662346-72749852 bp, + strand
From VEGA annotation of GRCm38

  87507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4

Human
homologs
Human Homolog NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NCBI Gene ID 4734
neXtProt AC  NX_P46934
Human Synonyms  NEDD4-1, RPF1
Human Chr (Location)  15q; chr15:55826917-55993746 (-)  GRCh38
Alleles
and
phenotypes
All alleles(157) : Targeted(5) Gene trapped(152)
 
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process adaptive immune response, blood vessel morphogenesis, ...
Component cell cortex, chromatin, ...
Function beta-2 adrenergic receptor binding, ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (422)    Tissues (81)    Images (57)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 367
Northern blot 10
RT-PCR 33
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000044728 (Evidence)
Ensembl Gene ModelENSMUSG00000032216 (Evidence)
Entrez Gene17999 (Evidence)
DFCITC1573666, TC1601002, TC1604410, TC1688850
DoTSDT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene IndexU010725
EC6.3.2.-
PDB3M7F
International Mouse Knockout Project StatusNedd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044728 VEGA Gene Model | MGI Sequence Detail 87507 C57BL/6J ±  kb
transcript OTTMUST00000117592 VEGA | MGI Sequence Detail 5499 Not Applicable 
polypeptide OTTMUSP00000065729 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(2) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000011115 E3 ubiquitin-protein ligase NEDD4
References (Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:196025 Guo H, et al., E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep. 2012 May 31;1(5):472-82
All references(83)
Other
accession IDs
MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory