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Nedd4
Gene Detail
 Symbol
Name
ID
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297
Synonyms E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:72662557-72749842 bp, + strand
From Ensembl annotation of GRCm38

  87286 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:88807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4
Human
homologs
Human Homolog NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NCBI Gene ID 4734
neXtProt AC  NX_P46934
Human Synonyms  NEDD4-1, RPF1
Human Chr (Location)  15q; chr15:56119120-56285835 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(157) : Targeted(5) Gene trapped(152)
 
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (79 annotations)
Process adaptive immune response, blood vessel morphogenesis, ...
Component cell cortex, chromatin, ...
Function beta-2 adrenergic receptor binding, ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (20 records)
Data Summary: Results (422)    Tissues (81)    Images (57)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 367
Northern blot 10
RT-PCR 33
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032216 (Evidence)
Entrez Gene17999 (Evidence)
DFCITC1573666, TC1601002, TC1604410, TC1688850
DoTSDT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene IndexU010725
EC6.3.2.-
PDB3M7F
International Mouse Knockout Project StatusNedd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032216 Ensembl Gene Model | MGI Sequence Detail 87286 C57BL/6J ±  kb
transcript ENSMUST00000034740 Ensembl | MGI Sequence Detail 5278 Not Applicable 
polypeptide ENSMUSP00000034740 Ensembl | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs(225 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR008973 C2 calcium/lipid-binding domain, CaLB
InterPro IPR020477 C2 domain
InterPro IPR018029 C2 membrane targeting protein
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW/Rsp5/WWP
Protein Ontology PR:000011115 E3 ubiquitin-protein ligase NEDD4
References (Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:192160 Nagpal P, et al., The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. PLoS One. 2012;7(10):e46427
All references(81)
Other
accession IDs 		MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory