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Nedd4 Gene Detail
Summary
  • Symbol
    Nedd4
  • Name
    neural precursor cell expressed, developmentally down-regulated 4
  • Synonyms
    E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:97297
    NCBI Gene: 17999
  • Gene Overview
    MyGene.info: NEDD4
Location & Maps
more
  • Sequence Map
    Chr9:72662346-72749852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87507 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    4
  • Human Ortholog
    NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    Orthology source: HGNC
  • Synonyms
    NEDD4-1, RPF1
  • Links
    NCBI Gene ID: 4734
    neXtProt AC: NX_P46934

  • Chr Location
    15q; chr15:55826917-55993746 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 7 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    159
  • Chemically induced (other)
    1
  • Gene trapped
    152
  • Targeted
    6
  • Genomic Mutations
    1 involving Nedd4
  • Incidental Mutations
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044728 VEGA Gene Model | MGI Sequence Detail 87507 C57BL/6J ±  kb
transcript OTTMUST00000117592 VEGA | MGI Sequence Detail 5499 Not Applicable  
polypeptide OTTMUSP00000065729 VEGA | MGI Sequence Detail 887 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    282 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 42
    cDNA 39
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188
References
more
  • Summaries
    All 90
    Developmental Gene Expression 23
    Gene Ontology 24
    Phenotypes 26
  • Earliest
    J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
  • Latest
    J:229488 Wiszniak S, et al., Cell autonomous roles of Nedd4 in craniofacial bone formation. Dev Biol. 2016 Feb 1;410(1):98-107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory