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Il3 Gene Detail
Summary
  • Symbol
    Il3
  • Name
    interleukin 3
  • Synonyms
    BPA, Csfmu, HCGF, Il-3, MCGF, PSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96552
    NCBI Gene: 16187
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54156129-54158103 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM, cytoband B1
  • Mapping Data
    63 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96552
 protein coding gene Chr11:54155911-54158105 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018313
 protein coding gene Chr11:53736423-53738398 (-)
A/J MGP_AJ_G0018282
 protein coding gene Chr11:51727318-51729293 (-)
AKR/J MGP_AKRJ_G0018251
 protein coding gene Chr11:53419331-53421305 (-)
BALB/cJ MGP_BALBcJ_G0018253
 protein coding gene Chr11:52069352-52071326 (-)
C3H/HeJ MGP_C3HHeJ_G0018064
 protein coding gene Chr11:53359172-53361147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018705
 protein coding gene Chr11:55388107-55390081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016355
 protein coding gene Chr11:49191657-49193624 (-)
CAST/EiJ MGP_CASTEiJ_G0017629
 protein coding gene Chr11:53406859-53408840 (-)
CBA/J MGP_CBAJ_G0018039
 protein coding gene Chr11:58008575-58010550 (-)
DBA/2J MGP_DBA2J_G0018148
 protein coding gene Chr11:51441982-51443956 (-)
FVB/NJ MGP_FVBNJ_G0018140
 protein coding gene Chr11:51084660-51086635 (-)
LP/J MGP_LPJ_G0018223
 protein coding gene Chr11:54184391-54186366 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018166
 protein coding gene Chr11:59223422-59225396 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018747
 protein coding gene Chr11:53440046-53442026 (-)
PWK/PhJ MGP_PWKPhJ_G0017402
 protein coding gene Chr11:51984126-51986106 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017197
 protein coding gene Chr11:53213869-53215829 (-)
WSB/EiJ MGP_WSBEiJ_G0017677
 protein coding gene Chr11:53068492-53070466 (-)



Homology
more
  • Human Ortholog
    IL3, interleukin 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL3, interleukin 3
  • Synonyms
    IL-3, MCGF, MULTI-CSF
  • Links
    NCBI Gene ID: 3562
    neXtProt AC: NX_P08700
    UniProt: P08700

  • Chr Location
    5q31.1; chr5:132060655-132063204 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IL3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    28 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    57
  • cDNA Data
    18
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018914 Ensembl Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
    transcript ENSMUST00000019058 Ensembl | MGI Sequence Detail 629 Not Applicable  
    polypeptide ENSMUSP00000019058 Ensembl | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 22
      cDNA 19
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11354, MGD-MRK-11379, MGD-MRK-2193
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 24
      Phenotypes 64
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345161 Benard A, et al., Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming. Front Immunol. 2023;14:1140630
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory