GO Annotations Graph

• Symbol: Zap70
• Name: zeta-chain (TCR) associated protein kinase
• ID: MGI:99613

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:35411
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	IPI	J:18500
Molecular Function	GO:0001784	phosphotyrosine residue binding	IPI	J:18500
Molecular Function	GO:0001784	phosphotyrosine residue binding	IPI	J:18500
Molecular Function	GO:0005515	protein binding	IPI	J:204615
Molecular Function	GO:0005515	protein binding	IPI	J:209882
Molecular Function	GO:0005515	protein binding	IPI	J:113565
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:112392
Molecular Function	GO:0005515	protein binding	IPI	J:35635
Molecular Function	GO:0004672	protein kinase activity	IDA	J:89761
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:35411
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:40949
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:41170
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	IDA	J:113565
Cellular Component	GO:0005829	cytosol	IDA	J:94701
Cellular Component	GO:0005829	cytosol	IDA	J:41090
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0001772	immunological synapse	IDA	J:113565
Cellular Component	GO:0016020	membrane	IDA	J:94701
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:113565
Cellular Component	GO:0042101	T cell receptor complex	ISO	J:18037
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0046632	alpha-beta T cell differentiation	IMP	J:27768
Biological Process	GO:0046632	alpha-beta T cell differentiation	IMP	J:41170
Biological Process	GO:0046632	alpha-beta T cell differentiation	IGI	J:42818
Biological Process	GO:0043366	beta selection	IGI	J:42818
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:41170
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:27768
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:27768
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:27768
Biological Process	GO:0045060	negative thymic T cell selection	IMP	J:27768
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:189787
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:41170
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:200103
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:35411
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IMP	J:27768
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IGI	J:42818
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IMP	J:27768
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IMP	J:41170
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IGI	J:42818
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IMP	J:27768
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IMP	J:41170
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:41170
Biological Process	GO:0045582	positive regulation of T cell differentiation	IMP	J:41170
Biological Process	GO:0045582	positive regulation of T cell differentiation	ISO	J:73065
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:27768
Biological Process	GO:0045059	positive thymic T cell selection	ISO	J:73065
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:41170
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:35411
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:40949
Biological Process	GO:0030217	T cell differentiation	IMP	J:41170
Biological Process	GO:0030217	T cell differentiation	IMP	J:41170
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:41170
Biological Process	GO:0045061	thymic T cell selection	IMP	J:41170
Biological Process	GO:0045061	thymic T cell selection	IMP	J:41170
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628