Syk GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Syk
spleen tyrosine kinase
MGI:99515

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:35411
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0016170	interleukin-15 receptor binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:326666
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IDA	J:31951
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	IPI	J:195394
Molecular Function	GO:0019902	phosphatase binding	IPI	J:237276
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245267
Molecular Function	GO:0005515	protein binding	IPI	J:116120
Molecular Function	GO:0005515	protein binding	IPI	J:114816
Molecular Function	GO:0005515	protein binding	IPI	J:129191
Molecular Function	GO:0005515	protein binding	IPI	J:226057
Molecular Function	GO:0005515	protein binding	IPI	J:143491
Molecular Function	GO:0005515	protein binding	IPI	J:195394
Molecular Function	GO:0005515	protein binding	IPI	J:195394
Molecular Function	GO:0005515	protein binding	IPI	J:144525
Molecular Function	GO:0005515	protein binding	IPI	J:97989
Molecular Function	GO:0005515	protein binding	IPI	J:200298
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:31951
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:110529
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:190693
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:129191
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:266145
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:305203
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:326666
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:237276
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:25526
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:35411
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:39598
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:29834
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0042169	SH2 domain binding	IDA	J:237276
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0035325	Toll-like receptor binding	IPI	J:195394
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0019815	B cell receptor complex	IDA	J:31951
Cellular Component	GO:0005737	cytoplasm	ISO	J:190693
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-442289
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5607754
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5621346
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607032
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676072
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0032009	early phagosome	IDA	J:97989
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:190693
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:190693
Cellular Component	GO:0032991	protein-containing complex	IDA	J:193006
Cellular Component	GO:0042101	T cell receptor complex	ISO	J:73065
Biological Process	GO:0002250	adaptive immune response	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0030183	B cell differentiation	IMP	J:29797
Biological Process	GO:0030183	B cell differentiation	IMP	J:29796
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:326666
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:29834
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:31951
Biological Process	GO:0043366	beta selection	IGI	J:42818
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:111210
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:37676
Biological Process	GO:0001775	cell activation	IMP	J:148372
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:39598
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:37676
Biological Process	GO:1990858	cellular response to lectin	IMP	J:148372
Biological Process	GO:0071396	cellular response to lipid	ISO	J:164563
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	IDA	J:227372
Biological Process	GO:0071226	cellular response to molecule of fungal origin	IMP	J:97989
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	IMP	J:237276
Biological Process	GO:0042742	defense response to bacterium	IMP	J:155479
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IDA	J:25526
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:37676
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:72653
Biological Process	GO:0042492	gamma-delta T cell differentiation	IMP	J:36147
Biological Process	GO:0042492	gamma-delta T cell differentiation	IMP	J:29796
Biological Process	GO:0032604	granulocyte macrophage colony-stimulating factor production	IMP	J:37676
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IMP	J:97989
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:180490
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:116120
Biological Process	GO:0032632	interleukin-3 production	IMP	J:37676
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	IMP	J:144525
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:148372
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:37676
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:31951
Biological Process	GO:0002366	leukocyte activation involved in immune response	IMP	J:97989
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	IMP	J:37676
Biological Process	GO:0001945	lymph vessel development	IMP	J:111210
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:116120
Biological Process	GO:0002281	macrophage activation involved in immune response	IBA	J:265628
Biological Process	GO:0032762	mast cell cytokine production	IMP	J:37676
Biological Process	GO:0032762	mast cell cytokine production	IMP	J:37676
Biological Process	GO:0043303	mast cell degranulation	IMP	J:37676
Biological Process	GO:0002283	neutrophil activation involved in immune response	IMP	J:116120
Biological Process	GO:0002283	neutrophil activation involved in immune response	IBA	J:265628
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:190693
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:129191
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:35411
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:29834
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:39598
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:37676
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IGI	J:42818
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IBA	J:265628
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IGI	J:42818
Biological Process	GO:0045579	positive regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0045579	positive regulation of B cell differentiation	IBA	J:265628
Biological Process	GO:0045579	positive regulation of B cell differentiation	IMP	J:29797
Biological Process	GO:0045579	positive regulation of B cell differentiation	IMP	J:29796
Biological Process	GO:0045579	positive regulation of B cell differentiation	IMP	J:29797
Biological Process	GO:0045579	positive regulation of B cell differentiation	IMP	J:29797
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:120084
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IMP	J:37676
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	IMP	J:180490
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:260043
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	IGI	J:153503
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:29796
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IMP	J:36147
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IMP	J:37676
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032752	positive regulation of interleukin-3 production	IMP	J:37676
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IMP	J:144525
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:37676
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:37676
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:31951
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	IMP	J:37676
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	IMP	J:37676
Biological Process	GO:0043306	positive regulation of mast cell degranulation	ISO	J:155856
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IBA	J:265628
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:37676
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:37676
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	IMP	J:178826
Biological Process	GO:0002092	positive regulation of receptor internalization	IMP	J:219170
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:178826
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:31951
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:35411
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:39598
Biological Process	GO:0006606	protein import into nucleus	ISO	J:190693
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	IDA	J:227372
Biological Process	GO:0090237	regulation of arachidonic acid secretion	IMP	J:40327
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	ISO	J:190693
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	IMP	J:155479
Biological Process	GO:0050776	regulation of immune response	ISO	J:155856
Biological Process	GO:0043313	regulation of neutrophil degranulation	IMP	J:155479
Biological Process	GO:0050764	regulation of phagocytosis	IMP	J:155479
Biological Process	GO:0010543	regulation of platelet activation	IMP	J:40327
Biological Process	GO:0090330	regulation of platelet aggregation	IMP	J:40327
Biological Process	GO:0090330	regulation of platelet aggregation	IBA	J:265628
Biological Process	GO:0032928	regulation of superoxide anion generation	IMP	J:155479
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0001820	serotonin secretion	IMP	J:37676
Biological Process	GO:0002554	serotonin secretion by platelet	IMP	J:40327
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	IMP	J:148372
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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