GO Annotations Graph

• Symbol: Plcg1
• Name: phospholipase C, gamma 1
• ID: MGI:97615

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0050429	calcium-dependent phospholipase C activity	ISO	J:155856
Molecular Function	GO:0035254	glutamate receptor binding	IPI	J:119025
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	EXP	J:266152
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:155856
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	IBA	J:265628
Molecular Function	GO:0004629	phospholipase C activity	IMP	J:253846
Molecular Function	GO:0004629	phospholipase C activity	ISO	J:317778
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:114724
Molecular Function	GO:0005515	protein binding	IPI	J:109624
Molecular Function	GO:0005515	protein binding	IPI	J:186446
Molecular Function	GO:0005515	protein binding	IPI	J:172887
Molecular Function	GO:0005515	protein binding	IPI	J:209882
Molecular Function	GO:0005515	protein binding	IPI	J:151074
Molecular Function	GO:0005515	protein binding	IPI	J:172064
Molecular Function	GO:0005515	protein binding	IPI	J:94701
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0005515	protein binding	IPI	J:237276
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:130626
Cellular Component	GO:0042995	cell projection	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0008180	COP9 signalosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:117528
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-1251929
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263481
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263481
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5621346
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-1251923
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-1251929
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9030433
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9030450
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9034794
Cellular Component	GO:0005886	plasma membrane	ISO	J:317778
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263481
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:263481
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001701	in utero embryonic development	IMP	J:75316
Biological Process	GO:0032959	inositol trisphosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0032957	inositol trisphosphate metabolic process	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:72247
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:263481
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:263481
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:263481
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:263481
Biological Process	GO:0031161	phosphatidylinositol catabolic process	ISO	J:155856
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:155856
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IBA	J:265628
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:72247
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IBA	J:265628
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0009306	protein secretion	ISO	J:155856
Biological Process	GO:1901339	regulation of store-operated calcium channel activity	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:1904643	response to curcumin	ISO	J:155856
Biological Process	GO:0010243	response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:96628