Msx2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Msx2
msh homeobox 2
MGI:97169

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:42570
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:196266
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	J:32834
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:32834
Molecular Function	GO:0005515	protein binding	IPI	J:143687
Molecular Function	GO:0005515	protein binding	IPI	J:77266
Molecular Function	GO:0005515	protein binding	IPI	J:67230
Molecular Function	GO:0005515	protein binding	IPI	J:64918
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	J:32834
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:94905
Molecular Function	GO:0008134	transcription factor binding	IPI	J:42570
Molecular Function	GO:0008134	transcription factor binding	IDA	J:42570
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007762
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:161903
Biological Process	GO:0090427	activation of meiosis	IPI	J:178676
Biological Process	GO:0042640	anagen	IMP	J:73670
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:171190
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:139946
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:138713
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:124119
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	IGI	J:139946
Biological Process	GO:0060349	bone morphogenesis	IGI	J:125119
Biological Process	GO:0060346	bone trabecula formation	IMP	J:61509
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:61509
Biological Process	GO:0051216	cartilage development	ISO	J:155856
Biological Process	GO:0051216	cartilage development	IMP	J:71946
Biological Process	GO:0051216	cartilage development	IMP	J:61509
Biological Process	GO:0042637	catagen	IMP	J:61509
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:35807
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:21055
Biological Process	GO:0002063	chondrocyte development	IMP	J:61509
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:171190
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:150759
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:98917
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:150759
Biological Process	GO:0048598	embryonic morphogenesis	IBA	J:265628
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IGI	J:171190
Biological Process	GO:0070166	enamel mineralization	IMP	J:61509
Biological Process	GO:0070166	enamel mineralization	IMP	J:61509
Biological Process	GO:0003416	endochondral bone growth	IMP	J:61509
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IGI	J:139946
Biological Process	GO:0060364	frontal suture morphogenesis	IMP	J:61509
Biological Process	GO:0061180	mammary gland epithelium development	IGI	J:61509
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:124119
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:124119
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IDA	J:91833
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:94905
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:91833
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	IMP	J:167662
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:32834
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:196266
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:161903
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:117610
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:42570
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:196266
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:91833
Biological Process	GO:0042476	odontogenesis	IMP	J:61509
Biological Process	GO:0001503	ossification	IMP	J:61509
Biological Process	GO:0002076	osteoblast development	IMP	J:61509
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:94905
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:124119
Biological Process	GO:0003148	outflow tract septum morphogenesis	IGI	J:124119
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IGI	J:139946
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	IGI	J:150759
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:91833
Biological Process	GO:0051795	positive regulation of timing of catagen	IMP	J:61509
Biological Process	GO:0042981	regulation of apoptotic process	IDA	J:138805
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IGI	J:171190
Biological Process	GO:0048863	stem cell differentiation	IGI	J:125119
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0042060	wound healing	IMP	J:167662
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	IMP	J:167662

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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