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GO Annotations Graph
Symbol
Name
ID
Lck
lymphocyte protein tyrosine kinase
MGI:96756

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003823antigen bindingISOJ:155856
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0051117ATPase bindingISOJ:164563
Molecular FunctionGO:0042609CD4 receptor bindingISOJ:164563
Molecular FunctionGO:0042609CD4 receptor bindingIPIJ:225417
Molecular FunctionGO:0042610CD8 receptor bindingISOJ:164563
Molecular FunctionGO:0001948glycoprotein bindingISOJ:164563
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0004715non-membrane spanning protein tyrosine kinase activityIBAJ:161428
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingISOJ:164563
Molecular FunctionGO:1990405protein antigen bindingIPIJ:170513
Molecular FunctionGO:0005515protein bindingIPIJ:159071
Molecular FunctionGO:0005515protein bindingIPIJ:115170
Molecular FunctionGO:0005515protein bindingIPIJ:116375
Molecular FunctionGO:0005515protein bindingIPIJ:166023
Molecular FunctionGO:0005515protein bindingIPIJ:58458
Molecular FunctionGO:0005515protein bindingIPIJ:165958
Molecular FunctionGO:0005515protein bindingIPIJ:100536
Molecular FunctionGO:0005515protein bindingIPIJ:200350
Molecular FunctionGO:0005515protein bindingIPIJ:159094
Molecular FunctionGO:0005515protein bindingIPIJ:166038
Molecular FunctionGO:0005515protein bindingIPIJ:55023
Molecular FunctionGO:0005515protein bindingIPIJ:96052
Molecular FunctionGO:0005515protein bindingIPIJ:200737
Molecular FunctionGO:0005515protein bindingIPIJ:96052
Molecular FunctionGO:0005515protein bindingIPIJ:175132
Molecular FunctionGO:0005515protein bindingIPIJ:204615
Molecular FunctionGO:0008022protein C-terminus bindingISOJ:164563
Molecular FunctionGO:0032403protein complex bindingISOJ:155856
Molecular FunctionGO:0004672protein kinase activityIEAJ:72247
Molecular FunctionGO:0019901protein kinase bindingISOJ:164563
Molecular FunctionGO:0019903protein phosphatase bindingISOJ:164563
Molecular FunctionGO:0004722protein serine/threonine phosphatase activityISOJ:164563
Molecular FunctionGO:0004713protein tyrosine kinase activityIDAJ:29834
Molecular FunctionGO:0004713protein tyrosine kinase activityIDAJ:17973
Molecular FunctionGO:0004713protein tyrosine kinase activityIMPJ:172064
Molecular FunctionGO:0004713protein tyrosine kinase activityIDAJ:40949
Molecular FunctionGO:0004713protein tyrosine kinase activityISOJ:155856
Molecular FunctionGO:0004713protein tyrosine kinase activityISOJ:164563
Molecular FunctionGO:0042169SH2 domain bindingISOJ:164563
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:0005911cell-cell junctionIDAJ:205441
Cellular ComponentGO:0005737cytoplasmIEAJ:60000
Cellular ComponentGO:0030139endocytic vesicleISOJ:155856
Cellular ComponentGO:0070062extracellular exosomeISOJ:164563
Cellular ComponentGO:0031234extrinsic component of cytoplasmic side of plasma membraneIBAJ:161428
Cellular ComponentGO:0001772immunological synapseISOJ:73065
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0045121membrane raftISOJ:164563
Cellular ComponentGO:0045121membrane raftISOJ:155856
Cellular ComponentGO:0000242pericentriolar materialISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0005886colocalizes_with
plasma membrane
IDAJ:225417
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processISOJ:164563
Biological ProcessGO:0050853B cell receptor signaling pathwayIDAJ:29834
Biological ProcessGO:0007166cell surface receptor signaling pathwayIDAJ:40461
Biological ProcessGO:0045087innate immune responseIBAJ:161428
Biological ProcessGO:0038083peptidyl-tyrosine autophosphorylationIBAJ:161428
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationISOJ:155856
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationIDAJ:29834
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationIDAJ:17973
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:0045588positive regulation of gamma-delta T cell differentiationIMPJ:22470
Biological ProcessGO:0010628positive regulation of gene expressionIDAJ:170688
Biological ProcessGO:2001244positive regulation of intrinsic apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0050870positive regulation of T cell activationISOJ:164563
Biological ProcessGO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDAJ:68671
Biological ProcessGO:0070474positive regulation of uterine smooth muscle contractionISOJ:155856
Biological ProcessGO:0046777protein autophosphorylationIDAJ:17973
Biological ProcessGO:0046777protein autophosphorylationISOJ:155856
Biological ProcessGO:0006470protein dephosphorylationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationIDAJ:40949
Biological ProcessGO:0042981regulation of apoptotic processIBAJ:161428
Biological ProcessGO:0042127regulation of cell proliferationIBAJ:161428
Biological ProcessGO:0045589regulation of regulatory T cell differentiationIGIJ:170513
Biological ProcessGO:0050856regulation of T cell receptor signaling pathwayIDAJ:90029
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolIDAJ:113700
Biological ProcessGO:0042493response to drugISOJ:164563
Biological ProcessGO:0042542response to hydrogen peroxideISOJ:155856
Biological ProcessGO:0009612response to mechanical stimulusISOJ:155856
Biological ProcessGO:0010038response to metal ionISOJ:155856
Biological ProcessGO:0030217T cell differentiationIBAJ:161428
Biological ProcessGO:0030217T cell differentiationISOJ:164563
Biological ProcessGO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIBAJ:161428


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory