Kdr GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Kdr
kinase insert domain protein receptor
MGI:96683

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	IGI	J:222928
Molecular Function	GO:0019838	growth factor binding	ISO	J:155856
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IPI	J:63336
Molecular Function	GO:0019838	growth factor binding	IPI	J:36300
Molecular Function	GO:0019838	growth factor binding	IPI	J:63336
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:245322
Molecular Function	GO:0005515	protein binding	IPI	J:190412
Molecular Function	GO:0005515	protein binding	IPI	J:195218
Molecular Function	GO:0005515	protein binding	IPI	J:166472
Molecular Function	GO:0005515	protein binding	IPI	J:200377
Molecular Function	GO:0005515	protein binding	IPI	J:234746
Molecular Function	GO:0005515	protein binding	IPI	J:88810
Molecular Function	GO:0005515	protein binding	IPI	J:159519
Molecular Function	GO:0005515	protein binding	IPI	J:203489
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:164563
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:164563
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IBA	J:265628
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IDA	J:91451
Cellular Component	GO:0030054	cell junction	IDA	J:152727
Cellular Component	GO:0071944	cell periphery	IDA	J:104149
Cellular Component	GO:0009986	cell surface	IDA	J:190263
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:191431
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005769	early endosome	IDA	J:197143
Cellular Component	GO:0005769	early endosome	IDA	J:166472
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:160232
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155850
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:191431
Cellular Component	GO:0005886	plasma membrane	IDA	J:166472
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:197143
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5218853
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0097443	sorting endosome	IDA	J:197143
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	TAS	J:164086
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IMP	J:96124
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IMP	J:96124
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	ISO	J:164563
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:104895
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:91451
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0045165	cell fate commitment	IMP	J:81796
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0016477	cell migration	IGI	J:95386
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IMP	J:166472
Biological Process	GO:1904881	cellular response to hydrogen sulfide	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:26846
Biological Process	GO:0003157	endocardium development	IMP	J:26846
Biological Process	GO:0003416	endochondral bone growth	ISO	J:155856
Biological Process	GO:0045446	endothelial cell differentiation	TAS	J:164086
Biological Process	GO:0045446	endothelial cell differentiation	IBA	J:265628
Biological Process	GO:0045446	endothelial cell differentiation	IMP	J:204805
Biological Process	GO:0045446	endothelial cell differentiation	IDA	J:84798
Biological Process	GO:0061154	endothelial tube morphogenesis	ISO	J:155856
Biological Process	GO:0003158	endothelium development	IMP	J:26846
Biological Process	GO:0002070	epithelial cell maturation	IMP	J:77480
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:104895
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	IMP	J:96124
Biological Process	GO:0048286	lung alveolus development	IMP	J:77480
Biological Process	GO:0030324	lung development	IMP	J:104895
Biological Process	GO:0001945	lymph vessel development	IGI	J:159519
Biological Process	GO:0008584	male gonad development	ISO	J:155856
Biological Process	GO:0010463	mesenchymal cell proliferation	IMP	J:104895
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:222928
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0001541	ovarian follicle development	IMP	J:121170
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IDA	J:166472
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IDA	J:164086
Biological Process	GO:0045766	positive regulation of angiogenesis	IBA	J:265628
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IDA	J:164086
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TAS	J:164086
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:104895
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:104895
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:73065
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:104895
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:104895
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	ISO	J:73065
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:73065
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:104895
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:104895
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:155856
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS	J:164086
Biological Process	GO:2001214	positive regulation of vasculogenesis	IMP	J:152727
Biological Process	GO:0048597	post-embryonic camera-type eye morphogenesis	IGI	J:183383
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:1903010	regulation of bone development	IMP	J:191431
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0001936	regulation of endothelial cell proliferation	TAS	J:164086
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	IMP	J:204805
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IGI	J:222928
Biological Process	GO:0072089	stem cell proliferation	IMP	J:104895
Biological Process	GO:0043129	surfactant homeostasis	IMP	J:77480
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IDA	J:91451
Biological Process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	ISO	J:164563
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0061042	vascular wound healing	ISO	J:164563
Biological Process	GO:0001570	vasculogenesis	IMP	J:26846
Biological Process	GO:0001570	vasculogenesis	IMP	J:96124
Biological Process	GO:0001570	vasculogenesis	IMP	J:96124
Biological Process	GO:0042311	vasodilation	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23