GO Annotations Graph

• Symbol: Slc6a4
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
• ID: MGI:96285

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	ISO	J:155856
Molecular Function	GO:0019811	cocaine binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	IMP	J:289076
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	ISO	J:100021
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	IMP	J:289076
Molecular Function	GO:0050998	nitric-oxide synthase binding	IPI	J:121594
Molecular Function	GO:0005515	protein binding	IPI	J:250837
Molecular Function	GO:0005515	protein binding	IPI	J:121594
Molecular Function	GO:0005515	protein binding	IPI	J:121594
Molecular Function	GO:0005515	protein binding	IPI	J:121594
Molecular Function	GO:0051378	serotonin binding	IBA	J:265628
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	ISO	J:155856
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	ISO	J:164563
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	IDA	J:37663
Molecular Function	GO:0005335	serotonin:sodium:chloride symporter activity	IBA	J:265628
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0012505	endomembrane system	ISO	J:164563
Cellular Component	GO:0012505	endomembrane system	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	IDA	J:250837
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0098793	presynapse	IMP	J:37663
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0099154	serotonergic synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:250837
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0048854	brain morphogenesis	IMP	J:144937
Biological Process	GO:0071321	cellular response to cGMP	ISO	J:155856
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:138764
Biological Process	GO:0007623	circadian rhythm	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0015844	monoamine transport	ISO	J:100021
Biological Process	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0046621	negative regulation of organ growth	IMP	J:144937
Biological Process	GO:0032227	negative regulation of synaptic transmission, dopaminergic	ISO	J:155856
Biological Process	GO:0098810	neurotransmitter reuptake	IDA	J:37663
Biological Process	GO:0098810	neurotransmitter reuptake	NAS	J:37663
Biological Process	GO:0098810	neurotransmitter reuptake	IMP	J:37663
Biological Process	GO:0006836	neurotransmitter transport	IMP	J:289076
Biological Process	GO:0045787	positive regulation of cell cycle	IMP	J:162980
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:162980
Biological Process	GO:0014064	positive regulation of serotonin secretion	ISO	J:155856
Biological Process	GO:0090067	regulation of thalamus size	ISO	J:164563
Biological Process	GO:0009636	response to toxic substance	ISO	J:164563
Biological Process	GO:0006837	serotonin transport	ISO	J:155856
Biological Process	GO:0006837	serotonin transport	IMP	J:162980
Biological Process	GO:0051610	serotonin uptake	IDA	J:121594
Biological Process	GO:0051610	serotonin uptake	IMP	J:289076
Biological Process	GO:0051610	serotonin uptake	ISO	J:164563
Biological Process	GO:0051610	serotonin uptake	IMP	J:76020
Biological Process	GO:0051610	serotonin uptake	ISO	J:155856
Biological Process	GO:0051610	serotonin uptake	IBA	J:265628
Biological Process	GO:0035176	social behavior	IGI	J:144937
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0042713	sperm ejaculation	ISO	J:155856
Biological Process	GO:0042310	vasoconstriction	ISO	J:155856