GO Annotations Graph

• Symbol: Egr1
• Name: early growth response 1
• ID: MGI:95295

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:149031
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:99386
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:34254
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:172948
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:154844
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0010385	double-stranded methylated DNA binding	ISO	J:164563
Molecular Function	GO:0044729	hemi-methylated DNA-binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:172948
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	J:34254
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:99386
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:164712
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9620402
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:66141
Cellular Component	GO:0005634	nucleus	IDA	J:154844
Cellular Component	GO:0005634	nucleus	IDA	J:33567
Cellular Component	GO:0005634	nucleus	IDA	J:149031
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:33445
Biological Process	GO:0071480	cellular response to gamma radiation	IMP	J:144234
Biological Process	GO:0071504	cellular response to heparin	ISO	J:155856
Biological Process	GO:0098759	cellular response to interleukin-8	ISO	J:164563
Biological Process	GO:0071506	cellular response to mycophenolic acid	ISO	J:155856
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:170688
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:267299
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:274077
Biological Process	GO:0060086	circadian temperature homeostasis	IMP	J:267299
Biological Process	GO:0044849	estrous cycle	IMP	J:35132
Biological Process	GO:0072110	glomerular mesangial cell proliferation	ISO	J:155856
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0045475	locomotor rhythm	IMP	J:267299
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:164712
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:101308
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:66141
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:154844
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:274077
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:23778
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:120888
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	ISO	J:155856
Biological Process	GO:0046886	positive regulation of hormone biosynthetic process	IMP	J:35132
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:66141
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1901875	positive regulation of post-translational protein modification	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:66141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:34254
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:35132
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:172948
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:193629
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:78245
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:2000182	regulation of progesterone biosynthetic process	IMP	J:35132
Biological Process	GO:0033233	regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA	J:149031
Biological Process	GO:0009749	response to glucose	IDA	J:154844
Biological Process	GO:0001666	response to hypoxia	IMP	J:66141
Biological Process	GO:0032868	response to insulin	IDA	J:154844
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0002931	response to ischemia	IMP	J:66141
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0030217	T cell differentiation	IMP	J:78245