GO Annotations Graph

• Symbol: Clu
• Name: clusterin
• ID: MGI:88423

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:82574
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0140597	protein carrier chaperone	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Cellular Component	GO:0016235	aggresome	ISO	J:155856
Cellular Component	GO:0097440	apical dendrite	ISO	J:164563
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:82574
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:274780
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:274780
Cellular Component	GO:0097418	neurofibrillary tangle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:82574
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0099020	perinuclear endoplasmic reticulum lumen	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:263376
Cellular Component	GO:0045202	synapse	EXP	J:263376
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0032286	central nervous system myelin maintenance	ISO	J:164563
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	ISO	J:164563
Biological Process	GO:0061077	chaperone-mediated protein folding	ISO	J:164563
Biological Process	GO:0031018	endocrine pancreas development	ISO	J:155856
Biological Process	GO:0002434	immune complex clearance	IMP	J:74983
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	ISO	J:164563
Biological Process	GO:0061518	microglial cell proliferation	ISO	J:164563
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	ISO	J:164563
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	IMP	J:107702
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IMP	J:78357
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:82574
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902998	positive regulation of neurofibrillary tangle assembly	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:78357
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0017038	protein import	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:155856
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	ISO	J:164563
Biological Process	GO:1900221	regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1901214	regulation of neuron death	ISO	J:164563
Biological Process	GO:1902847	regulation of neuronal signal transduction	ISO	J:164563
Biological Process	GO:0051788	response to misfolded protein	ISO	J:164563