GO Annotations Graph

• Symbol: Piezo1
• Name: piezo-type mechanosensitive ion channel component 1
• ID: MGI:3603204

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	IPI	J:247395
Molecular Function	GO:0042802	identical protein binding	IPI	J:245270
Molecular Function	GO:0042802	identical protein binding	IPI	J:273510
Molecular Function	GO:0042802	identical protein binding	IPI	J:273541
Molecular Function	GO:0042802	identical protein binding	IPI	J:256306
Molecular Function	GO:0140135	mechanosensitive monoatomic cation channel activity	IMP	J:292721
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	IBA	J:265628
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	IDA	J:164433
Molecular Function	GO:0005261	monoatomic cation channel activity	IMP	J:164433
Molecular Function	GO:0005261	monoatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0005261	monoatomic cation channel activity	IDA	J:164433
Molecular Function	GO:0005515	protein binding	IPI	J:256306
Molecular Function	GO:0005515	protein binding	IPI	J:256306
Molecular Function	GO:0005515	protein binding	IPI	J:217259
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:164433
Biological Process	GO:0071260	cellular response to mechanical stimulus	IBA	J:265628
Biological Process	GO:0050982	detection of mechanical stimulus	IBA	J:265628
Biological Process	GO:0050982	detection of mechanical stimulus	IMP	J:164433
Biological Process	GO:0098655	monoatomic cation transmembrane transport	IDA	J:164433
Biological Process	GO:0006812	monoatomic cation transport	IMP	J:164433
Biological Process	GO:0006812	monoatomic cation transport	IMP	J:292721
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0033625	positive regulation of integrin activation	ISO	J:164563
Biological Process	GO:0010831	positive regulation of myotube differentiation	ISO	J:164563
Biological Process	GO:0010831	positive regulation of myotube differentiation	IMP	J:262981
Biological Process	GO:0042391	regulation of membrane potential	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:164433