GO Annotations Graph

• Symbol: Dna2
• Name: DNA replication helicase/nuclease 2
• ID: MGI:2443732

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ISO	J:164563
Molecular Function	GO:0017108	5'-flap endonuclease activity	ISO	J:164563
Molecular Function	GO:0017108	5'-flap endonuclease activity	IDA	J:198831
Molecular Function	GO:0017108	5'-flap endonuclease activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0004386	helicase activity	IEA	J:72247
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:198831
Molecular Function	GO:0003723	RNA binding	IBA	J:265628
Molecular Function	GO:0017116	single-stranded DNA helicase activity	ISO	J:164563
Molecular Function	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:198831
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005760	gamma DNA polymerase complex	ISO	J:164563
Cellular Component	GO:0042645	mitochondrial nucleoid	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0000729	DNA double-strand break processing	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006260	DNA replication	ISO	J:164563
Biological Process	GO:0000076	DNA replication checkpoint signaling	ISO	J:164563
Biological Process	GO:0033567	DNA replication, Okazaki fragment processing	ISO	J:164563
Biological Process	GO:0043137	DNA replication, removal of RNA primer	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043504	mitochondrial DNA repair	ISO	J:164563
Biological Process	GO:0006264	mitochondrial DNA replication	ISO	J:164563
Biological Process	GO:1902990	mitotic telomere maintenance via semi-conservative replication	IMP	J:198831
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IDA	J:198831
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:0071932	replication fork reversal	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IMP	J:198831