GO Annotations Graph

• Symbol: Rtel1
• Name: regulator of telomere elongation helicase 1
• ID: MGI:2139369

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003678	DNA helicase activity	ISO	J:164563
Molecular Function	GO:0003678	DNA helicase activity	IDA	J:202812
Molecular Function	GO:0003678	DNA helicase activity	IBA	J:265628
Molecular Function	GO:0070182	DNA polymerase binding	IPI	J:202812
Molecular Function	GO:0070182	DNA polymerase binding	IBA	J:265628
Molecular Function	GO:0004386	helicase activity	TAS	J:222674
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA	J:72247
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:202812
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:222674
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:91351
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0032508	DNA duplex unwinding	IDA	J:202812
Biological Process	GO:0032508	DNA duplex unwinding	IBA	J:265628
Biological Process	GO:0006310	DNA recombination	IEA	J:72247
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006260	DNA replication	IEA	J:72247
Biological Process	GO:1902990	mitotic telomere maintenance via semi-conservative replication	IDA	J:202812
Biological Process	GO:0045910	negative regulation of DNA recombination	IDA	J:222674
Biological Process	GO:0045910	negative regulation of DNA recombination	IBA	J:265628
Biological Process	GO:1904430	negative regulation of t-circle formation	ISO	J:164563
Biological Process	GO:1904430	negative regulation of t-circle formation	IMP	J:202812
Biological Process	GO:1904430	negative regulation of t-circle formation	IMP	J:222674
Biological Process	GO:1904430	negative regulation of t-circle formation	IBA	J:265628
Biological Process	GO:1904506	negative regulation of telomere maintenance in response to DNA damage	IMP	J:222674
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	IEA	J:72247
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	IMP	J:222674
Biological Process	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	ISO	J:164563
Biological Process	GO:1904535	positive regulation of telomeric loop disassembly	IDA	J:222674
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0031297	replication fork processing	IDA	J:202812
Biological Process	GO:0000732	strand displacement	IDA	J:222674
Biological Process	GO:0000723	telomere maintenance	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IMP	J:91351
Biological Process	GO:0043247	telomere maintenance in response to DNA damage	IMP	J:222674
Biological Process	GO:0061820	telomeric D-loop disassembly	TAS	J:222674
Biological Process	GO:0090657	telomeric loop disassembly	IDA	J:222674
Biological Process	GO:0090657	telomeric loop disassembly	ISO	J:164563
Biological Process	GO:0090657	telomeric loop disassembly	IMP	J:202812
Biological Process	GO:0090657	telomeric loop disassembly	IBA	J:265628