GO Annotations Graph

• Symbol: Stub1
• Name: STIP1 homology and U-Box containing protein 1
• ID: MGI:1891731

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	TAS	J:104594
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0035033	histone deacetylase regulator activity	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISS	J:64910
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	TAS	J:104594
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISS	J:64910
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0051787	misfolded protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:104594
Molecular Function	GO:0005515	protein binding	IPI	J:248244
Molecular Function	GO:0005515	protein binding	IPI	J:198827
Molecular Function	GO:0005515	protein binding	IPI	J:104594
Molecular Function	GO:0005515	protein binding	IPI	J:156684
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:104594
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	IBA	J:265628
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TAS	J:104594
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0030911	TPR domain binding	ISO	J:164563
Molecular Function	GO:0030911	TPR domain binding	ISS	J:64910
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:239897
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:183193
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:183193
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TAS	J:104594
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	IDA	J:71263
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:257327
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISS	J:64910
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0042405	nuclear inclusion body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0101031	protein folding chaperone complex	ISO	J:164563
Cellular Component	GO:0031371	ubiquitin conjugating enzyme complex	TAS	J:104594
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:156684
Biological Process	GO:0034605	cellular response to heat	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0071218	cellular response to misfolded protein	ISO	J:164563
Biological Process	GO:0071218	cellular response to misfolded protein	IMP	J:183193
Biological Process	GO:0071218	cellular response to misfolded protein	IBA	J:265628
Biological Process	GO:0061684	chaperone-mediated autophagy	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:212816
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:212816
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0090035	positive regulation of chaperone-mediated protein complex assembly	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS	J:64910
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:212816
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISS	J:64910
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045862	positive regulation of proteolysis	IBA	J:265628
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	IDA	J:212816
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:183193
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0006457	protein folding	TAS	J:104594
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0051604	protein maturation	TAS	J:104594
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:71263
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	ISO	J:164563
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IMP	J:183193
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	TAS	J:104594
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IDA	J:239897
Biological Process	GO:0031943	regulation of glucocorticoid metabolic process	ISO	J:164563
Biological Process	GO:0031943	regulation of glucocorticoid metabolic process	ISS	J:64910
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:132677
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:239897
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	ISO	J:164563