GO Annotations Graph

• Symbol: Klf2
• Name: Kruppel-like transcription factor 2 (lung)
• ID: MGI:1342772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISS	J:97532
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISA	J:29401
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114067
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:178114
Biological Process	GO:0000902	cell morphogenesis	IMP	J:119377
Biological Process	GO:0071498	cellular response to fluid shear stress	ISO	J:164563
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:0097533	cellular stress response to acid chemical	ISO	J:164563
Biological Process	GO:0040029	epigenetic regulation of gene expression	IGI	J:185718
Biological Process	GO:0034101	erythrocyte homeostasis	IMP	J:119377
Biological Process	GO:0043249	erythrocyte maturation	IMP	J:119377
Biological Process	GO:0001701	in utero embryonic development	IMP	J:51402
Biological Process	GO:0001701	in utero embryonic development	IMP	J:119377
Biological Process	GO:0035264	multicellular organism growth	IMP	J:119377
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:29401
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0048386	positive regulation of retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:119377
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:178114
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:119377
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060509	type I pneumocyte differentiation	IMP	J:178114
Biological Process	GO:0042311	vasodilation	ISO	J:164563