Hey2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hey2
hairy/enhancer-of-split related with YRPW motif 2
MGI:1341884

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IMP	J:121581
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:175191
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISS	J:62860
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:101349
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0005515	protein binding	IPI	J:175191
Molecular Function	GO:0005515	protein binding	IPI	J:101349
Molecular Function	GO:0005515	protein binding	IPI	J:175112
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0005515	protein binding	IPI	J:65682
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:185205
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:108520
Cellular Component	GO:0005737	cytoplasm	IDA	J:175314
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2065441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008180
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:175314
Cellular Component	GO:0005634	nucleus	IDA	J:121581
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	ISS	J:58781
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009948	anterior/posterior axis specification	IGI	J:96337
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0003180	aortic valve morphogenesis	IDA	J:261827
Biological Process	GO:0060842	arterial endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0060840	artery development	IGI	J:96337
Biological Process	GO:0035910	ascending aorta morphogenesis	IMP	J:79025
Biological Process	GO:0060413	atrial septum morphogenesis	IMP	J:79025
Biological Process	GO:0003171	atrioventricular valve development	IMP	J:97120
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0001568	blood vessel development	IGI	J:96337
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IGI	J:89444
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	IMP	J:133699
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	IMP	J:79025
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	IMP	J:160578
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0003300	cardiac muscle hypertrophy	IMP	J:160578
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IDA	J:108520
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	IMP	J:79025
Biological Process	GO:0060411	cardiac septum morphogenesis	IMP	J:119923
Biological Process	GO:0060948	cardiac vascular smooth muscle cell development	IMP	J:165754
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:101349
Biological Process	GO:0045165	cell fate commitment	IMP	J:144981
Biological Process	GO:0072359	circulatory system development	IBA	J:265628
Biological Process	GO:0090102	cochlea development	IMP	J:135642
Biological Process	GO:0090102	cochlea development	IGI	J:135642
Biological Process	GO:0090102	cochlea development	IGI	J:135642
Biological Process	GO:0060977	coronary vasculature morphogenesis	IMP	J:165754
Biological Process	GO:0035912	dorsal aorta morphogenesis	IGI	J:89444
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	IGI	J:96337
Biological Process	GO:0060347	heart trabecula formation	IMP	J:119923
Biological Process	GO:0060716	labyrinthine layer blood vessel development	IGI	J:89444
Biological Process	GO:0014031	mesenchymal cell development	IMP	J:133699
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0003150	muscular septum morphogenesis	IMP	J:79025
Biological Process	GO:0070168	negative regulation of biomineral tissue development	IDA	J:261827
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:160578
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:101349
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:175191
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:101495
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:185205
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:160578
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IDA	J:175159
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:121581
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:101495
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175314
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:261827
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:60859
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	IDA	J:175159
Biological Process	GO:0060633	negative regulation of transcription initiation by RNA polymerase II	ISO	J:164563
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IDA	J:175159
Biological Process	GO:0061314	Notch signaling involved in heart development	IC	J:79025
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:155856
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:64398
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:79025
Biological Process	GO:0007389	pattern specification process	IGI	J:135642
Biological Process	GO:0007389	pattern specification process	IGI	J:135642
Biological Process	GO:0007389	pattern specification process	IMP	J:135642
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:133798
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:97120
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:89444
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:133699
Biological Process	GO:0065004	protein-DNA complex assembly	IDA	J:60859
Biological Process	GO:0065004	protein-DNA complex assembly	IDA	J:108520
Biological Process	GO:0061156	pulmonary artery morphogenesis	IMP	J:79025
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:79025
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:165754
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	IGI	J:144981
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISS	J:58781
Biological Process	GO:2001212	regulation of vasculogenesis	IGI	J:89444
Biological Process	GO:0003195	tricuspid valve formation	IMP	J:97120
Biological Process	GO:0003186	tricuspid valve morphogenesis	IMP	J:79025
Biological Process	GO:0036304	umbilical cord morphogenesis	IGI	J:89444
Biological Process	GO:0001570	vasculogenesis	IGI	J:89444
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IMP	J:133798
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:79025
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IGI	J:96337

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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