GO Annotations Graph

• Symbol: Sort1
• Name: sortilin 1
• ID: MGI:1338015

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0048406	nerve growth factor binding	ISO	J:164563
Molecular Function	GO:0010465	nerve growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0030379	neurotensin receptor activity, non-G protein-coupled	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:136228
Molecular Function	GO:0005515	protein binding	IPI	J:193410
Molecular Function	GO:0005515	protein binding	IPI	J:159842
Molecular Function	GO:0005515	protein binding	IPI	J:167062
Molecular Function	GO:0005515	protein binding	IPI	J:208015
Molecular Function	GO:0005515	protein binding	IPI	J:170255
Molecular Function	GO:0005515	protein binding	IPI	J:149884
Molecular Function	GO:0005515	protein binding	IPI	J:216244
Molecular Function	GO:0005515	protein binding	IPI	J:216244
Molecular Function	GO:1905394	retromer complex binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IMP	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	IDA	J:80816
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	IDA	J:234039
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:99400
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0030140	trans-Golgi network transport vesicle	IDA	J:89488
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006897	endocytosis	ISO	J:164563
Biological Process	GO:0006897	endocytosis	IBA	J:265628
Biological Process	GO:0006897	endocytosis	IMP	J:206213
Biological Process	GO:0008333	endosome to lysosome transport	ISO	J:164563
Biological Process	GO:0032509	endosome transport via multivesicular body sorting pathway	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046323	glucose import	IMP	J:99400
Biological Process	GO:0046323	glucose import	ISO	J:164563
Biological Process	GO:0006895	Golgi to endosome transport	ISO	J:164563
Biological Process	GO:0006895	Golgi to endosome transport	IBA	J:265628
Biological Process	GO:0090160	Golgi to lysosome transport	ISO	J:164563
Biological Process	GO:0099558	maintenance of synapse structure	IMP	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0014902	myotube differentiation	ISO	J:164563
Biological Process	GO:0014902	myotube differentiation	IMP	J:133006
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:216244
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:164563
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:0048227	plasma membrane to endosome transport	ISO	J:164563
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	ISO	J:155856
Biological Process	GO:0006622	protein targeting to lysosome	IMP	J:154468
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0032868	response to insulin	IMP	J:99400
Biological Process	GO:0032868	response to insulin	ISO	J:164563
Biological Process	GO:0016050	vesicle organization	ISO	J:164563
Biological Process	GO:0016050	vesicle organization	IMP	J:99400
Biological Process	GO:0016050	vesicle organization	IBA	J:265628