Blm GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Blm
Bloom syndrome, RecQ like helicase
MGI:1328362

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043138	3'-5' DNA helicase activity	IBA	J:265628
Molecular Function	GO:0043138	3'-5' DNA helicase activity	IDA	J:51306
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ISO	J:164563
Molecular Function	GO:0000405	bubble DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003678	DNA helicase activity	ISO	J:164563
Molecular Function	GO:1990814	DNA/DNA annealing activity	ISO	J:164563
Molecular Function	GO:0061749	forked DNA-dependent helicase activity	ISO	J:164563
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0009378	four-way junction helicase activity	ISO	J:164563
Molecular Function	GO:0009378	four-way junction helicase activity	IBA	J:265628
Molecular Function	GO:0051880	G-quadruplex DNA binding	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:296112
Molecular Function	GO:0005515	protein binding	IPI	J:92518
Molecular Function	GO:0005515	protein binding	IPI	J:92518
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0061821	telomeric D-loop binding	ISO	J:164563
Molecular Function	GO:0061849	telomeric G-quadruplex DNA binding	ISO	J:164563
Molecular Function	GO:0000403	Y-form DNA binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IBA	J:265628
Cellular Component	GO:0000781	chromosome, telomeric region	IMP	J:227293
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:131948
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000800	lateral element	ISO	J:164563
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:123677
Cellular Component	GO:0000228	nuclear chromosome	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:296112
Cellular Component	GO:0005634	nucleus	NAS	J:319969
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0045120	pronucleus	IDA	J:131948
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0031422	RecQ family helicase-topoisomerase III complex	ISO	J:164563
Cellular Component	GO:0005657	replication fork	IMP	J:227293
Cellular Component	GO:0005657	replication fork	IDA	J:92518
Biological Process	GO:0046632	alpha-beta T cell differentiation	IMP	J:118992
Biological Process	GO:0046632	alpha-beta T cell differentiation	IMP	J:118992
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0044237	cellular metabolic process	IEA	J:72247
Biological Process	GO:0072757	cellular response to camptothecin	ISO	J:164563
Biological Process	GO:0072711	cellular response to hydroxyurea	ISO	J:164563
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:1901655	cellular response to ketone	IGI	J:223244
Biological Process	GO:0071407	cellular response to organic cyclic compound	IGI	J:223244
Biological Process	GO:0071417	cellular response to organonitrogen compound	IGI	J:223244
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IGI	J:223244
Biological Process	GO:0051276	chromosome organization	IMP	J:50843
Biological Process	GO:0051276	chromosome organization	IMP	J:93771
Biological Process	GO:1904157	DN4 thymocyte differentiation	IMP	J:118992
Biological Process	GO:1904157	DN4 thymocyte differentiation	IMP	J:118992
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0000729	DNA double-strand break processing	ISO	J:164563
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0006310	DNA recombination	IEA	J:72247
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0006260	DNA replication	IMP	J:227293
Biological Process	GO:0006260	DNA replication	IGI	J:227293
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	IBA	J:265628
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IGI	J:227293
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IMP	J:227293
Biological Process	GO:0044806	G-quadruplex DNA unwinding	ISO	J:164563
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IBA	J:265628
Biological Process	GO:0033080	immature T cell proliferation in thymus	IMP	J:118992
Biological Process	GO:0033080	immature T cell proliferation in thymus	IMP	J:118992
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0006312	mitotic recombination	IMP	J:66261
Biological Process	GO:0006312	mitotic recombination	IMP	J:66261
Biological Process	GO:0006312	mitotic recombination	IMP	J:118992
Biological Process	GO:0006312	mitotic recombination	IMP	J:118992
Biological Process	GO:0006312	mitotic recombination	IMP	J:50843
Biological Process	GO:0051782	negative regulation of cell division	ISO	J:164563
Biological Process	GO:0045910	negative regulation of DNA recombination	ISO	J:164563
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:235782
Biological Process	GO:0045950	negative regulation of mitotic recombination	IGI	J:235782
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:50843
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:66261
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:112115
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:118992
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:66261
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:118992
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IGI	J:118922
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:118922
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IMP	J:118992
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	IGI	J:223244
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IMP	J:118992
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IMP	J:118992
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0051098	regulation of binding	IDA	J:92518
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0090329	regulation of DNA-templated DNA replication	ISO	J:164563
Biological Process	GO:0031297	replication fork processing	ISO	J:164563
Biological Process	GO:0031297	replication fork processing	IMP	J:296112
Biological Process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	IMP	J:223224
Biological Process	GO:0071139	resolution of recombination intermediates	ISO	J:164563
Biological Process	GO:0010165	response to X-ray	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IGI	J:93016
Biological Process	GO:0000723	telomere maintenance	IGI	J:93016
Biological Process	GO:0061820	telomeric D-loop disassembly	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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