GO Annotations Graph

• Symbol: Tet1
• Name: tet methylcytosine dioxygenase 1
• ID: MGI:1098693

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008327	methyl-CpG binding	ISO	J:164563
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:148409
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	ISO	J:164563
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:175793
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172063
Molecular Function	GO:0005515	protein binding	IPI	J:196207
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220931
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220936
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220944
Cellular Component	GO:0005634	nucleus	IDA	J:148409
Cellular Component	GO:0005634	nucleus	NAS	J:243422
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:163464
Cellular Component	GO:0016580	Sin3 complex	NAS	J:243422
Biological Process	GO:0006211	5-methylcytosine catabolic process	IEA	J:72247
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:230884
Biological Process	GO:0080111	DNA demethylation	IMP	J:175307
Biological Process	GO:0080111	DNA demethylation	ISO	J:164563
Biological Process	GO:0080111	DNA demethylation	IMP	J:148409
Biological Process	GO:0080111	DNA demethylation	IBA	J:265628
Biological Process	GO:0080111	DNA demethylation	IDA	J:163464
Biological Process	GO:0001826	inner cell mass cell differentiation	IMP	J:148409
Biological Process	GO:0001826	inner cell mass cell differentiation	IMP	J:168828
Biological Process	GO:0001826	inner cell mass cell differentiation	IMP	J:163464
Biological Process	GO:0030336	negative regulation of cell migration	NAS	J:320045
Biological Process	GO:0090310	negative regulation of DNA methylation-dependent heterochromatin formation	ISO	J:164563
Biological Process	GO:1902455	negative regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NAS	J:320043
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	NAS	J:320045
Biological Process	GO:0070989	oxidative demethylation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:196207
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006493	protein O-linked glycosylation	IMP	J:196207
Biological Process	GO:0044030	regulation of DNA methylation	IMP	J:168828
Biological Process	GO:2000653	regulation of genetic imprinting	IMP	J:207929
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:148409