GO Annotations Graph

• Symbol: Fer
• Name: FER tyrosine kinase
• ID: MGI:105917

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0045296	cadherin binding	ISO	J:155856
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0070097	delta-catenin binding	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0045295	gamma-catenin binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:78852
Molecular Function	GO:0005515	protein binding	IPI	J:84709
Molecular Function	GO:0005515	protein binding	IPI	J:84709
Molecular Function	GO:0004672	protein kinase activity	IDA	J:78594
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0008157	protein phosphatase 1 binding	IPI	J:183970
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0045098	type III intermediate filament	ISO	J:155856
Biological Process	GO:0031532	actin cytoskeleton reorganization	IMP	J:107107
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IMP	J:78594
Biological Process	GO:0008283	cell population proliferation	IEA	J:72247
Biological Process	GO:0044331	cell-cell adhesion mediated by cadherin	IMP	J:107107
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:66245
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	IMP	J:125059
Biological Process	GO:0006935	chemotaxis	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IMP	J:78594
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0050904	diapedesis	IMP	J:183972
Biological Process	GO:0035426	extracellular matrix-cell signaling	IMP	J:125059
Biological Process	GO:0038095	Fc-epsilon receptor signaling pathway	IMP	J:78594
Biological Process	GO:0038095	Fc-epsilon receptor signaling pathway	IBA	J:265628
Biological Process	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	IDA	J:66245
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038109	Kit signaling pathway	IMP	J:78594
Biological Process	GO:0000226	microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	IMP	J:116450
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	J:183980
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:78594
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78594
Biological Process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:125059
Biological Process	GO:0010591	regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0043304	regulation of mast cell degranulation	IBA	J:265628
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:183970
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:183972
Biological Process	GO:0036119	response to platelet-derived growth factor	IDA	J:183980
Biological Process	GO:0007165	signal transduction	IDA	J:78594
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IMP	J:107107
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	ISO	J:164563