GO Annotations Graph

• Symbol: Hspa8
• Name: heat shock protein 8
• ID: MGI:105384

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031686	A1 adenosine receptor binding	ISO	J:155856
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	IBA	J:265628
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:73065
Molecular Function	GO:0016887	ATP hydrolysis activity	IDA	J:82317
Molecular Function	GO:0140545	ATP-dependent protein disaggregase activity	ISO	J:164563
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone	IEA	J:72247
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	ISO	J:164563
Molecular Function	GO:1990833	clathrin-uncoating ATPase activity	ISO	J:155856
Molecular Function	GO:1990833	clathrin-uncoating ATPase activity	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0001786	phosphatidylserine binding	IDA	J:227378
Molecular Function	GO:1904593	prostaglandin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:233627
Molecular Function	GO:0005515	protein binding	IPI	J:327046
Molecular Function	GO:0005515	protein binding	IPI	J:223937
Molecular Function	GO:0005515	protein binding	IPI	J:157586
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:156684
Molecular Function	GO:0005515	protein binding	IPI	J:137305
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:86751
Molecular Function	GO:0005515	protein binding	IPI	J:137305
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0044183	protein folding chaperone	IBA	J:265628
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:155856
Molecular Function	GO:0051082	unfolded protein binding	IPI	J:82317
Molecular Function	GO:0051082	unfolded protein binding	IPI	J:82317
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0005776	autophagosome	ISO	J:155856
Cellular Component	GO:0005776	autophagosome	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:233627
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9613507
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9613545
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9613562
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9613670
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9631076
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9631080
Cellular Component	GO:0005829	cytosol	IDA	J:110647
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	IDA	J:154189
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263412
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:263412
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263412
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:167979
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:167979
Cellular Component	GO:0098690	glycinergic synapse	ISO	J:155856
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:167979
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:167979
Cellular Component	GO:0005882	intermediate filament	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:39331
Cellular Component	GO:0005770	late endosome	IDA	J:227378
Cellular Component	GO:0031906	late endosome lumen	TAS	Reactome:R-MMU-9631080
Cellular Component	GO:1990836	lysosomal matrix	ISO	J:155856
Cellular Component	GO:1990836	lysosomal matrix	ISO	J:73065
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:155856
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:73065
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:1990124	messenger ribonucleoprotein complex	ISO	J:155856
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0044309	neuron spine	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:97418
Cellular Component	GO:0001917	photoreceptor inner segment	ISO	J:155856
Cellular Component	GO:0098684	photoreceptor ribbon synapse	IDA	J:250267
Cellular Component	GO:0098684	photoreceptor ribbon synapse	IDA	J:250267
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0099524	postsynaptic cytosol	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:167979
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:167979
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:167979
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:167979
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	IDA	J:250267
Cellular Component	GO:0098793	presynapse	IDA	J:250267
Cellular Component	GO:0098793	presynapse	IPI	J:169031
Cellular Component	GO:0098793	presynapse	IPI	J:169031
Cellular Component	GO:0098793	presynapse	IDA	J:169031
Cellular Component	GO:0098793	presynapse	IEP	J:169031
Cellular Component	GO:0098793	presynapse	IMP	J:169031
Cellular Component	GO:0098793	presynapse	IDA	J:169031
Cellular Component	GO:0099523	presynaptic cytosol	ISO	J:155856
Cellular Component	GO:0099523	presynaptic cytosol	IBA	J:265628
Cellular Component	GO:0101031	protein folding chaperone complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0000974	Prp19 complex	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:0005681	spliceosomal complex	ISO	J:164563
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	IBA	J:265628
Biological Process	GO:0046034	ATP metabolic process	ISO	J:164563
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	IBA	J:265628
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	IGI	J:86751
Biological Process	GO:0061684	chaperone-mediated autophagy	ISO	J:73065
Biological Process	GO:1904764	chaperone-mediated autophagy translocation complex disassembly	IBA	J:265628
Biological Process	GO:0061077	chaperone-mediated protein folding	IDA	J:169031
Biological Process	GO:0061077	chaperone-mediated protein folding	IEP	J:169031
Biological Process	GO:0061077	chaperone-mediated protein folding	IDA	J:169031
Biological Process	GO:0061077	chaperone-mediated protein folding	IPI	J:169031
Biological Process	GO:0061077	chaperone-mediated protein folding	IMP	J:169031
Biological Process	GO:0061077	chaperone-mediated protein folding	IPI	J:169031
Biological Process	GO:0072318	clathrin coat disassembly	IBA	J:265628
Biological Process	GO:0072318	clathrin coat disassembly	IGI	J:158574
Biological Process	GO:0072318	clathrin coat disassembly	IGI	J:158574
Biological Process	GO:0061738	late endosomal microautophagy	IMP	J:227378
Biological Process	GO:0061738	late endosomal microautophagy	IBA	J:265628
Biological Process	GO:0044788	modulation by host of viral process	IMP	J:233627
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0000398	mRNA splicing, via spliceosome	NAS	J:320339
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1902904	negative regulation of supramolecular fiber organization	ISO	J:164563
Biological Process	GO:0044829	positive regulation by host of viral genome replication	IMP	J:233627
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	IMP	J:204486
Biological Process	GO:0006457	protein folding	IDA	J:82317
Biological Process	GO:0042026	protein refolding	ISO	J:164563
Biological Process	GO:0042026	protein refolding	IBA	J:265628
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	ISO	J:164563
Biological Process	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	IBA	J:265628
Biological Process	GO:0032984	protein-containing complex disassembly	ISO	J:73065
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:82317
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:263412
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:263412
Biological Process	GO:0099175	regulation of postsynapse organization	EXP	J:263412
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0008380	RNA splicing	IEA	J:60000
Biological Process	GO:1990832	slow axonal transport	IBA	J:265628