Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including clathrin coat disassembly; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within chaperone cofactor-dependent protein refolding; positive regulation of mRNA splicing, via spliceosome; and regulation of cell cycle. Located in several cellular components, including extracellular exosome; late endosome; and perinuclear region of cytoplasm. Is active in several cellular components, including glycinergic synapse; photoreceptor ribbon synapse; and postsynaptic specialization membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).