About   Help   FAQ
GO Annotations Graph
Symbol
Name
ID
Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0003677DNA bindingIEAJ:72247
Molecular FunctionGO:0004677DNA-dependent protein kinase activityIDAJ:204750
Molecular FunctionGO:0004677DNA-dependent protein kinase activityISOJ:73065
Molecular FunctionGO:0003690double-stranded DNA bindingIDAJ:173439
Molecular FunctionGO:0019899enzyme bindingIPIJ:168151
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0016773phosphotransferase activity, alcohol group as acceptorIEAJ:72247
Molecular FunctionGO:0044822poly(A) RNA bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:207239
Molecular FunctionGO:0005515protein bindingIPIJ:212794
Molecular FunctionGO:0004672protein kinase activityISOJ:164563
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:164563
Molecular FunctionGO:0008134transcription factor bindingISOJ:164563
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:0005958DNA-dependent protein kinase-DNA ligase 4 complexISOJ:73065
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0070419nonhomologous end joining complexISOJ:164563
Cellular ComponentGO:0000784nuclear chromosome, telomeric regionISOJ:164563
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:82010
Cellular ComponentGO:0005667transcription factor complexISOJ:164563
Biological ProcessGO:0002326B cell lineage commitmentIMPJ:31364
Biological ProcessGO:0007420brain developmentIGIJ:108789
Biological ProcessGO:0008283cell proliferationISOJ:164563
Biological ProcessGO:0006974cellular response to DNA damage stimulusIEAJ:60000
Biological ProcessGO:0032869cellular response to insulin stimulusISOJ:164563
Biological ProcessGO:0006281DNA repairIEAJ:60000
Biological ProcessGO:0006302double-strand break repairIMPJ:73443
Biological ProcessGO:0006302double-strand break repairIMPJ:82010
Biological ProcessGO:0006302double-strand break repairISOJ:164563
Biological ProcessGO:0006303double-strand break repair via nonhomologous end joiningIMPJ:204750
Biological ProcessGO:0035234ectopic germ cell programmed cell deathIMPJ:118902
Biological ProcessGO:0007507heart developmentIGIJ:108789
Biological ProcessGO:0002377immunoglobulin productionISOJ:155856
Biological ProcessGO:0033152immunoglobulin V(D)J recombinationIMPJ:50222
Biological ProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIMPJ:82010
Biological ProcessGO:0030098lymphocyte differentiationIMPJ:17426
Biological ProcessGO:0043066negative regulation of apoptotic processISOJ:164563
Biological ProcessGO:2000773negative regulation of cellular senescenceISOJ:155856
Biological ProcessGO:0002638negative regulation of immunoglobulin productionISOJ:155856
Biological ProcessGO:0001933negative regulation of protein phosphorylationIMPJ:207239
Biological ProcessGO:2001229negative regulation of response to gamma radiationISOJ:155856
Biological ProcessGO:0018105peptidyl-serine phosphorylationISOJ:73065
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:0043065positive regulation of apoptotic processIMPJ:118902
Biological ProcessGO:0048639positive regulation of developmental growthISOJ:155856
Biological ProcessGO:0048146positive regulation of fibroblast proliferationISOJ:155856
Biological ProcessGO:0002684positive regulation of immune system processISOJ:155856
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0002328pro-B cell differentiationIMPJ:50222
Biological ProcessGO:0031648protein destabilizationIDAJ:92391
Biological ProcessGO:0042752regulation of circadian rhythmIMPJ:207239
Biological ProcessGO:0048660regulation of smooth muscle cell proliferationISOJ:164563
Biological ProcessGO:0010332response to gamma radiationIMPJ:50222
Biological ProcessGO:0010212response to ionizing radiationIMPJ:173439
Biological ProcessGO:0048511rhythmic processIEAJ:60000
Biological ProcessGO:0072431signal transduction involved in mitotic G1 DNA damage checkpointISOJ:164563
Biological ProcessGO:0001756somitogenesisIGIJ:108789
Biological ProcessGO:0048536spleen developmentISOJ:155856
Biological ProcessGO:0033077T cell differentiation in thymusIMPJ:50222
Biological ProcessGO:0002360T cell lineage commitmentIMPJ:31364
Biological ProcessGO:0033153T cell receptor V(D)J recombinationIMPJ:50222
Biological ProcessGO:0016233telomere cappingISOJ:164563
Biological ProcessGO:0000723telomere maintenanceIMPJ:88560
Biological ProcessGO:0048538thymus developmentISOJ:155856
Biological ProcessGO:0033151V(D)J recombinationIGIJ:204750


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/14/2021
MGI 6.17
The Jackson Laboratory