Prkdc GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	ISO	J:73065
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	IDA	J:204750
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:173439
Molecular Function	GO:0019899	enzyme binding	IPI	J:168151
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:207239
Molecular Function	GO:0005515	protein binding	IPI	J:212794
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0034511	U3 snoRNA binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0070418	DNA-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	ISO	J:73065
Cellular Component	GO:0070419	nonhomologous end joining complex	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:82010
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0032040	small-subunit processome	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0007420	brain development	IGI	J:108789
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IBA	J:265628
Biological Process	GO:0006302	double-strand break repair	IMP	J:73443
Biological Process	GO:0006302	double-strand break repair	IMP	J:82010
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NAS	J:320262
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:204750
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:118902
Biological Process	GO:0007507	heart development	IGI	J:108789
Biological Process	GO:0002327	immature B cell differentiation	IMP	J:50222
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IBA	J:265628
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IMP	J:50222
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:82010
Biological Process	GO:0030098	lymphocyte differentiation	IMP	J:17426
Biological Process	GO:0000460	maturation of 5.8S rRNA	ISO	J:164563
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:155856
Biological Process	GO:0002638	negative regulation of immunoglobulin production	ISO	J:155856
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:207239
Biological Process	GO:2001229	negative regulation of response to gamma radiation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:118902
Biological Process	GO:0048639	positive regulation of developmental growth	ISO	J:155856
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:287062
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0002684	positive regulation of immune system process	ISO	J:155856
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	IMP	J:287062
Biological Process	GO:1905221	positive regulation of platelet formation	IMP	J:287062
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	IMP	J:287062
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:50222
Biological Process	GO:0031648	protein destabilization	IDA	J:92391
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:207239
Biological Process	GO:0050678	regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	IMP	J:287062
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0010332	response to gamma radiation	IMP	J:50222
Biological Process	GO:0010212	response to ionizing radiation	IMP	J:173439
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0042254	ribosome biogenesis	IEA	J:60000
Biological Process	GO:0034462	small-subunit processome assembly	ISO	J:164563
Biological Process	GO:0001756	somitogenesis	IGI	J:108789
Biological Process	GO:0048536	spleen development	ISO	J:155856
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:50222
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0033153	T cell receptor V(D)J recombination	IMP	J:50222
Biological Process	GO:0016233	telomere capping	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IMP	J:88560
Biological Process	GO:0048538	thymus development	ISO	J:155856
Biological Process	GO:0033151	V(D)J recombination	IGI	J:204750

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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