Erbb4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Erbb4
erb-b2 receptor tyrosine kinase 4
MGI:104771

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IGI	J:82728
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0050811	GABA receptor binding	IDA	J:202968
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0038132	neuregulin binding	ISO	J:32778
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:34905
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:247763
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:42826
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:42826
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:247763
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:306781
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:223042
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:42983
Molecular Function	GO:0038131	neuregulin receptor activity	IMP	J:157327
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:34905
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:177160
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:317052
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0060077	inhibitory synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0031594	neuromuscular junction	IMP	J:180660
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:180660
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:202968
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:316875
Cellular Component	GO:0005886	plasma membrane	ISO	J:42826
Cellular Component	GO:0005886	plasma membrane	ISO	J:42826
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	IDA	J:274112
Cellular Component	GO:0005886	plasma membrane	IDA	J:306781
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	ISO	J:223042
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	IDA	J:82728
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:42983
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:317052
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:202968
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0061026	cardiac muscle tissue regeneration	IMP	J:157327
Biological Process	GO:0045165	cell fate commitment	IDA	J:80421
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:202968
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	IDA	J:34905
Biological Process	GO:0021551	central nervous system morphogenesis	IMP	J:60190
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:60190
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IGI	J:82728
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IDA	J:47407
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IDA	J:34905
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:42826
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IMP	J:247763
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IMP	J:106042
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:223042
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:247763
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:34905
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:42826
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:306781
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:47407
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:42983
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:317052
Biological Process	GO:0072046	establishment of planar polarity involved in nephron morphogenesis	IMP	J:180153
Biological Process	GO:0007507	heart development	IMP	J:29972
Biological Process	GO:0007595	lactation	IMP	J:178286
Biological Process	GO:0007595	lactation	ISO	J:164563
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:178286
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IMP	J:114489
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IMP	J:29972
Biological Process	GO:0001755	neural crest cell migration	IMP	J:60190
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:180660
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:180660
Biological Process	GO:0021889	olfactory bulb interneuron differentiation	IMP	J:95821
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:157327
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:114489
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:136701
Biological Process	GO:0071073	positive regulation of phospholipid biosynthetic process	ISO	J:155856
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	IGI	J:136701
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IMP	J:114489
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:114489
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:178286
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0030334	regulation of cell migration	IMP	J:95821
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0043129	surfactant homeostasis	ISO	J:155856
Biological Process	GO:0007416	synapse assembly	IDA	J:159459
Biological Process	GO:0007416	synapse assembly	IMP	J:159459
Biological Process	GO:0007416	synapse assembly	IDA	J:159459
Biological Process	GO:0060074	synapse maturation	ISO	J:155856
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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