Ppara GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ppara
peroxisome proliferator activated receptor alpha
MGI:104740

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:114735
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IDA	J:85352
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051525	NFAT protein binding	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0003707	nuclear steroid receptor activity	ISO	J:164563
Molecular Function	GO:0003707	nuclear steroid receptor activity	TAS	J:56056
Molecular Function	GO:0019902	phosphatase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0005515	protein binding	IPI	J:129744
Molecular Function	GO:0005515	protein binding	IPI	J:255965
Molecular Function	GO:0005515	protein binding	IPI	J:43438
Molecular Function	GO:0005515	protein binding	IPI	J:177497
Molecular Function	GO:0005515	protein binding	IPI	J:138823
Molecular Function	GO:0005515	protein binding	IPI	J:251809
Molecular Function	GO:0005515	protein binding	IPI	J:114735
Molecular Function	GO:0005515	protein binding	IPI	J:114735
Molecular Function	GO:0005515	protein binding	IPI	J:162572
Molecular Function	GO:0005515	protein binding	IPI	J:162572
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:91368
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:78038
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:114735
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IDA	J:90488
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	IDA	J:91368
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-879764
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:56056
Biological Process	GO:0035095	behavioral response to nicotine	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0009267	cellular response to starvation	IMP	J:194781
Biological Process	GO:0032922	circadian regulation of gene expression	IDA	J:156994
Biological Process	GO:0070166	enamel mineralization	IMP	J:147982
Biological Process	GO:0008544	epidermis development	IMP	J:81021
Biological Process	GO:0006631	fatty acid metabolic process	ISO	J:155856
Biological Process	GO:0006631	fatty acid metabolic process	TAS	J:56056
Biological Process	GO:0006631	fatty acid metabolic process	IMP	J:46203
Biological Process	GO:0006631	fatty acid metabolic process	IMP	J:90430
Biological Process	GO:0006094	gluconeogenesis	IMP	J:91368
Biological Process	GO:0006006	glucose metabolic process	TAS	J:56056
Biological Process	GO:0009755	hormone-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	TAS	J:56056
Biological Process	GO:0042157	lipoprotein metabolic process	ISO	J:155856
Biological Process	GO:0032099	negative regulation of appetite	IMP	J:85352
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0010887	negative regulation of cholesterol storage	ISO	J:164563
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0045820	negative regulation of glycolytic process	ISO	J:164563
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:1903038	negative regulation of leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:155856
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:164563
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	ISO	J:164563
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:85352
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:90430
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	IMP	J:95532
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IMP	J:91368
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:194781
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:19422
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162572
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:113484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:162572
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162572
Biological Process	GO:0045070	positive regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IDA	J:156994
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:56056
Biological Process	GO:0019217	regulation of fatty acid metabolic process	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:92097
Biological Process	GO:0019216	regulation of lipid metabolic process	IBA	J:265628
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0042060	wound healing	IMP	J:71272

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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