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GO Annotations Graph
Symbol
Name
ID
Brca1
breast cancer 1, early onset
MGI:104537

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003682chromatin bindingISOJ:155856
Molecular FunctionGO:0043773coenzyme F420-0 gamma-glutamyl ligase activityIEAJ:72245
Molecular FunctionGO:0043774coenzyme F420-2 alpha-glutamyl ligase activityIEAJ:72245
Molecular FunctionGO:0003684damaged DNA bindingIDAJ:76360
Molecular FunctionGO:0003677DNA bindingIEAJ:72247
Molecular FunctionGO:0003677DNA bindingIEAJ:60000
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0016874ligase activityIEAJ:60000
Molecular FunctionGO:0046872metal ion bindingIEAJ:72247
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0070739protein-glutamic acid ligase activityIEAJ:72245
Molecular FunctionGO:0070735protein-glycine ligase activityIEAJ:72245
Molecular FunctionGO:0070737protein-glycine ligase activity, elongatingIEAJ:72245
Molecular FunctionGO:0070736protein-glycine ligase activity, initiatingIEAJ:72245
Molecular FunctionGO:0018169ribosomal S6-glutamic acid ligase activityIEAJ:72245
Molecular FunctionGO:0003723RNA bindingISOJ:79872
Molecular FunctionGO:0044212transcription regulatory region DNA bindingIDAJ:173146
Molecular FunctionGO:0044212transcription regulatory region DNA bindingISOJ:164563
Molecular FunctionGO:0070740tubulin-glutamic acid ligase activityIEAJ:72245
Molecular FunctionGO:0070738tubulin-glycine ligase activityIEAJ:72245
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:164563
Molecular FunctionGO:0004842ubiquitin-protein transferase activityISOJ:164563
Molecular FunctionGO:0004842ubiquitin-protein transferase activityIBAJ:161428
Molecular FunctionGO:0008766UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activityIEAJ:72245
Molecular FunctionGO:0008270zinc ion bindingIEAJ:72247
Cellular ComponentGO:0070531BRCA1-A complexIBAJ:161428
Cellular ComponentGO:0070531BRCA1-A complexISOJ:164563
Cellular ComponentGO:0031436BRCA1-BARD1 complexIBAJ:161428
Cellular ComponentGO:0031436BRCA1-BARD1 complexISOJ:164563
Cellular ComponentGO:0005813centrosomeTASJ:113897
Cellular ComponentGO:0005694chromosomeIDAJ:192634
Cellular ComponentGO:0005694chromosomeIDAJ:183982
Cellular ComponentGO:0000793condensed chromosomeIDAJ:85108
Cellular ComponentGO:0000794condensed nuclear chromosomeIDAJ:161203
Cellular ComponentGO:0005737cytoplasmIDAJ:74101
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0030529intracellular ribonucleoprotein complexISOJ:142821
Cellular ComponentGO:0005759mitochondrial matrixISOJ:155856
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneIBAJ:161428
Cellular ComponentGO:0043234protein complexISOJ:164563
Biological ProcessGO:0007049cell cycleIEAJ:60000
Biological ProcessGO:0006974cellular response to DNA damage stimulusIMPJ:192592
Biological ProcessGO:0071681cellular response to indole-3-methanolISOJ:164563
Biological ProcessGO:0071356cellular response to tumor necrosis factorISOJ:164563
Biological ProcessGO:0007098centrosome cycleIGIJ:91673
Biological ProcessGO:0051298centrosome duplicationTASJ:113897
Biological ProcessGO:0043009chordate embryonic developmentIMPJ:40594
Biological ProcessGO:0031052chromosome breakageIGIJ:197442
Biological ProcessGO:0007059chromosome segregationISOJ:164563
Biological ProcessGO:0006310DNA recombinationIEAJ:60000
Biological ProcessGO:0006281DNA repairIEAJ:60000
Biological ProcessGO:0006281DNA repairIEAJ:72247
Biological ProcessGO:0006260DNA replicationIMPJ:92253
Biological ProcessGO:0009048dosage compensation by inactivation of X chromosomeIDAJ:79872
Biological ProcessGO:0006302double-strand break repairISOJ:164563
Biological ProcessGO:0006302double-strand break repairIMPJ:205643
Biological ProcessGO:0000724double-strand break repair via homologous recombinationIBAJ:161428
Biological ProcessGO:0000724double-strand break repair via homologous recombinationISOJ:164563
Biological ProcessGO:0006633fatty acid biosynthetic processIEAJ:60000
Biological ProcessGO:0006631fatty acid metabolic processIEAJ:60000
Biological ProcessGO:0031572G2 DNA damage checkpointISOJ:164563
Biological ProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageISOJ:87001
Biological ProcessGO:0006629lipid metabolic processIEAJ:60000
Biological ProcessGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsISOJ:164563
Biological ProcessGO:0045717negative regulation of fatty acid biosynthetic processIBAJ:161428
Biological ProcessGO:0045717negative regulation of fatty acid biosynthetic processISOJ:164563
Biological ProcessGO:0035067negative regulation of histone acetylationIMPJ:173146
Biological ProcessGO:0051572negative regulation of histone H3-K4 methylationIMPJ:173146
Biological ProcessGO:0051573negative regulation of histone H3-K9 methylationIMPJ:173146
Biological ProcessGO:0051573negative regulation of histone H3-K9 methylationISOJ:164563
Biological ProcessGO:0033147negative regulation of intracellular estrogen receptor signaling pathwayISOJ:164563
Biological ProcessGO:2000378negative regulation of reactive oxygen species metabolic processISOJ:164563
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0045766positive regulation of angiogenesisISOJ:164563
Biological ProcessGO:0071158positive regulation of cell cycle arrestIBAJ:161428
Biological ProcessGO:0071158positive regulation of cell cycle arrestISOJ:164563
Biological ProcessGO:0045739positive regulation of DNA repairISOJ:164563
Biological ProcessGO:0010628positive regulation of gene expressionISOJ:164563
Biological ProcessGO:0035066positive regulation of histone acetylationISOJ:164563
Biological ProcessGO:0035066positive regulation of histone acetylationIMPJ:173146
Biological ProcessGO:0051571positive regulation of histone H3-K4 methylationISOJ:164563
Biological ProcessGO:0051571positive regulation of histone H3-K4 methylationIMPJ:173146
Biological ProcessGO:2000617positive regulation of histone H3-K9 acetylationISOJ:164563
Biological ProcessGO:2000617positive regulation of histone H3-K9 acetylationIMPJ:173146
Biological ProcessGO:0051574positive regulation of histone H3-K9 methylationIMPJ:173146
Biological ProcessGO:2000620positive regulation of histone H4-K16 acetylationISOJ:164563
Biological ProcessGO:2000620positive regulation of histone H4-K16 acetylationIMPJ:173146
Biological ProcessGO:0070512positive regulation of histone H4-K20 methylationIMPJ:173146
Biological ProcessGO:0070512positive regulation of histone H4-K20 methylationISOJ:164563
Biological ProcessGO:0033160positive regulation of protein import into nucleus, translocationISOJ:155856
Biological ProcessGO:0031398positive regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:173146
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedISOJ:164563
Biological ProcessGO:0010575positive regulation of vascular endothelial growth factor productionISOJ:164563
Biological ProcessGO:0006301postreplication repairISOJ:164563
Biological ProcessGO:0051865protein autoubiquitinationISOJ:164563
Biological ProcessGO:0085020protein K6-linked ubiquitinationISOJ:164563
Biological ProcessGO:0016567protein ubiquitinationISOJ:164563
Biological ProcessGO:0042127regulation of cell proliferationIBAJ:161428
Biological ProcessGO:0044030regulation of DNA methylationIMPJ:173146
Biological ProcessGO:0006349regulation of gene expression by genetic imprintingIMPJ:173146
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0043627response to estrogenISOJ:164563
Biological ProcessGO:0010212response to ionizing radiationISOJ:164563
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory