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Defb35 Gene Detail
Summary
  • Symbol
    Defb35
  • Name
    defensin beta 35
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179204
    NCBI Gene: 246084
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22428368-22430894 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.66 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179204
 protein coding gene Chr8:22428368-22430894 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033438
 protein coding gene Chr8:19772763-19772981 (+)
A/J MGP_AJ_G0033418
 protein coding gene Chr8:19126934-19127152 (+)
AKR/J MGP_AKRJ_G0033343
 protein coding gene Chr8:19758288-19758506 (+)
BALB/cJ MGP_BALBcJ_G0033414
 protein coding gene Chr8:19251252-19251470 (+)
C3H/HeJ MGP_C3HHeJ_G0033128
 protein coding gene Chr8:19952440-19952658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033905
 protein coding gene Chr8:17133833-17134051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030871
 protein coding gene Chr8:15309801-15310018 (-)
CAST/EiJ MGP_CASTEiJ_G0032454
 protein coding gene Chr8:19379742-19379960 (+)
CBA/J MGP_CBAJ_G0033103
 protein coding gene Chr8:21442535-21442753 (+)
DBA/2J MGP_DBA2J_G0033258
 protein coding gene Chr8:19101678-19101896 (+)
FVB/NJ MGP_FVBNJ_G0033202
 protein coding gene Chr8:18901194-18901412 (+)
LP/J MGP_LPJ_G0033347
 protein coding gene Chr8:19782620-19782838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033245
 protein coding gene Chr8:21046487-21046705 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033922
 protein coding gene Chr8:16516836-16517054 (-)
PWK/PhJ MGP_PWKPhJ_G0032166
 protein coding gene Chr8:18696203-18696421 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031999
 protein coding gene Chr8:19049619-19049836 (+)
WSB/EiJ MGP_WSBEiJ_G0032544
 protein coding gene Chr8:16614108-16614326 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246084 NCBI Gene Model | MGI Sequence Detail 2527 C57BL/6J ±  kb
transcript NM_139224 RefSeq | MGI Sequence Detail 267 C57BL/6  
polypeptide Q8R2I3 UniProt | EBI | MGI Sequence Detail 63 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 17
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:82526 Morrison GM, et al., Signal Sequence Conservation and Mature Peptide Divergence Within Subgroups of the Murine beta-Defensin Gene Family. Mol Biol Evol. 2003 Mar;20(3):460-70
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory