Nr2c1 MGI Mouse Gene Detail - MGI:1352465 - nuclear receptor subfamily 2, group C, member 1

Symbol

Nr2c1
Name

nuclear receptor subfamily 2, group C, member 1
Synonyms

4831444H07Rik, Eenr, TR2, Tr2-11

Feature Type

protein coding gene
IDs

MGI:1352465
NCBI Gene: 22025
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:93983885-94033073 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 48.81 cM
Mapping Data

2 experiments

SNPs within 2kb

544 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352465	protein coding gene	Chr10:93983491-94033078 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017661	protein coding gene	Chr10:95612167-95667412 (+)
A/J	MGP_AJ_G0017640	protein coding gene	Chr10:92261129-92310514 (+)
AKR/J	MGP_AKRJ_G0017598	protein coding gene	Chr10:94903081-94952991 (+)
BALB/cJ	MGP_BALBcJ_G0017603	protein coding gene	Chr10:92535506-92589303 (+)
C3H/HeJ	MGP_C3HHeJ_G0017426	protein coding gene	Chr10:94897843-94948432 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018060	protein coding gene	Chr10:98766921-98820466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015741	protein coding gene	Chr10:87844640-87895224 (+)
CAST/EiJ	MGP_CASTEiJ_G0016991	protein coding gene	Chr10:94902521-94953364 (+)
CBA/J	MGP_CBAJ_G0017395	protein coding gene	Chr10:102851283-102911337 (+)
DBA/2J	MGP_DBA2J_G0017501	protein coding gene	Chr10:91355778-91405163 (+)
FVB/NJ	MGP_FVBNJ_G0017493	protein coding gene	Chr10:90595893-90645455 (+)
LP/J	MGP_LPJ_G0017575	protein coding gene	Chr10:96220503-96270674 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017524	protein coding gene	Chr10:104113218-104165696 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018097	protein coding gene	Chr10:94806058-94859522 (+)
PWK/PhJ	MGP_PWKPhJ_G0016772	protein coding gene	Chr10:91451711-91501578 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016560	protein coding gene	Chr10:93604832-93665760 (+)
WSB/EiJ	MGP_WSBEiJ_G0017050	protein coding gene	Chr10:94771708-94822545 (+)

Human Ortholog

NR2C1, nuclear receptor subfamily 2 group C member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NR2C1, nuclear receptor subfamily 2 group C member 1
Synonyms

TR2
Links

HGNC:7971

NCBI Gene ID: 7181

neXtProt AC: NX_P13056

UniProt: P13056
Chr Location

12q22; chr12:95020229-95073628 (-) GRCh38

MGI Vertebrate Homology

Nr2c1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NR2C1
Gene Tree

Nr2c1

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

29
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Nr2c1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available

Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in testis development or in spermatogenesis; no gross defects were detected in the central nervous system and normal motor neuron cell numbers were noted.

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All GO Annotations

27
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1008
Tissues

221
cDNA Data

20
Literature Summary

18

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nr2c1

ZFIN nr2c1

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All Sequences

52
RefSeq

7
UniProt

1
CCDS

CCDS24131.1

Ensembl

ENSMUSG00000005897 (Evidence)
NCBI Gene

22025

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005897	Ensembl Gene Model \| MGI Sequence Detail	49189	C57BL/6J	± kb
transcript	ENSMUST00000092213	Ensembl \| MGI Sequence Detail	2376	Not Applicable
polypeptide	ENSMUSP00000089858	Ensembl \| MGI Sequence Detail	590	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011399 nuclear receptor subfamily 2 group C member 1

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR048245 Nuclear receptor subfamily 2 group C member 1/2-like, DNA-binding domain

IPR048246 Nuclear receptor subfamily 2 group C member 1/2-like, ligand binding domain

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 34

Genomic 7

cDNA 20

Primer pair 5

Other 2

Microarray probesets 8

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MGD-MRK-26050, MGD-MRK-26100, MGI:104613, MGI:104660, MGI:2443924

Summaries

All 77

Developmental Gene Expression 18

Gene Ontology 13

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:248772 Olivares AM, et al., The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 Sep 1;429(1):343-355

TSS for Nr2c1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95305	Chr10:93983769-93983828 (+)	-86 bp
Tssr95306	Chr10:93983844-93983871 (+)	-27 bp
Tssr95307	Chr10:93998140-93998159 (+)	14,265 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23