Prcd MGI Mouse Gene Detail - MGI:3649529 - photoreceptor disc component

Symbol

Prcd
Name

photoreceptor disc component
Synonyms

Gm11744

Feature Type

protein coding gene
IDs

MGI:3649529
NCBI Gene: 100038570
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:116544603-116559224 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.46 cM

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3649529	protein coding gene	Chr11:116544360-116559224 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019435	protein coding gene	Chr11:120798986-120814770 (+)
A/J	MGP_AJ_G0019403	protein coding gene	Chr11:115508383-115523749 (+)
AKR/J	MGP_AKRJ_G0019374	protein coding gene	Chr11:118944850-118966522 (+)
BALB/cJ	MGP_BALBcJ_G0019378	protein coding gene	Chr11:115904648-115919866 (+)
C3H/HeJ	MGP_C3HHeJ_G0019184	protein coding gene	Chr11:119304674-119322793 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019827	protein coding gene	Chr11:124493782-124511995 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017451	protein coding gene	Chr11:112521732-112535777 (+)
CAST/EiJ	MGP_CASTEiJ_G0018739	protein coding gene	Chr11:120681087-120696226 (+)
CBA/J	MGP_CBAJ_G0019155	protein coding gene	Chr11:129410686-129426295 (+)
DBA/2J	MGP_DBA2J_G0019267	protein coding gene	Chr11:114934192-114949111 (+)
FVB/NJ	MGP_FVBNJ_G0019259	protein coding gene	Chr11:114444992-114462467 (+)
LP/J	MGP_LPJ_G0019337	protein coding gene	Chr11:121182415-121198571 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019292	protein coding gene	Chr11:128443109-128458120 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019866	protein coding gene	Chr11:119608752-119623239 (+)
PWK/PhJ	MGP_PWKPhJ_G0018503	protein coding gene	Chr11:116262272-116277306 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018296	protein coding gene	Chr11:119359570-119373929 (+)
WSB/EiJ	MGP_WSBEiJ_G0018791	protein coding gene	Chr11:119576889-119592325 (+)

Human Ortholog

PRCD, photoreceptor disc component

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRCD, photoreceptor disc component
Synonyms

RP36
Links

HGNC:32528

NCBI Gene ID: 768206

neXtProt AC: NX_Q00LT1

UniProt: Q00LT1
Chr Location

17q25.1; chr17:76527586-76553580 (+) GRCh38

MGI Vertebrate Homology

Prcd stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: PRCD
Gene Tree

Prcd

Diseases

1 with human PRCD associations

				Human Disease	Mouse Models
				retinitis pigmentosa 36 IDs retinitis pigmentosa 36 DOID:0110405 ICD10CM:H35.5 MESH:C566431 OMIM:610599

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Gene trapped

31
Targeted

3
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show a defect in photoreceptor disc morphogenesis resulting in vesicle accumulation in the inter-photoreceptor space and a slow progressive retinal rod cell degeneration.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

4
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

46
RefSeq

13
UniProt

3
CCDS

CCDS48987.1

Ensembl

ENSMUSG00000075410 (Evidence)
NCBI Gene

100038570

			Length	Strain/Species	Flank
genomic	100038570	NCBI Gene Model \| MGI Sequence Detail	14622	C57BL/6J	± kb
transcript	NM_001163318	RefSeq \| MGI Sequence Detail	816	C57BL/6
polypeptide	Q00LT2	UniProt \| EBI \| MGI Sequence Detail	53	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013178 photoreceptor disk component PRCD

(term hierarchy)
InterPro Domains

IPR027937 Photoreceptor disk component PRCD

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:303922 Remez L, et al., TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. Int J Mol Sci. 2020 Nov 17;21(22):8677

TSS for Prcd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105977	Chr11:116547932-116547943 (+)	3,335 bp
Tssr105978	Chr11:116547949-116547966 (+)	3,355 bp
Tssr3741	Chr11:116547977-116547978 (+)	3,375 bp
Tssr105979	Chr11:116548339-116548362 (+)	3,748 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23