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Gzma Gene Detail
Summary
  • Symbol
    Gzma
  • Name
    granzyme A
  • Synonyms
    BLT esterase, Ctla3, Ctla-3, Hanukah factor, Hf, H factor, SE1, serine esterase 1, TSP1, TSP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109266
    NCBI Gene: 14938
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:113230359-113237515 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.93 cM, cytoband D
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109266
 protein coding gene Chr13:113230358-113237515 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020948
 protein coding gene Chr13:115708748-115715902 (-)
A/J MGP_AJ_G0020898
 protein coding gene Chr13:111077371-111098224 (-)
AKR/J MGP_AKRJ_G0020873
 protein coding gene Chr13:114425712-114432866 (-)
BALB/cJ MGP_BALBcJ_G0020898
 protein coding gene Chr13:111774457-111781611 (-)
C3H/HeJ MGP_C3HHeJ_G0020687
 protein coding gene Chr13:114221649-114228803 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021334
 protein coding gene Chr13:119139748-119146900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018903
 protein coding gene Chr13:106369861-106375404 (-)
CAST/EiJ MGP_CASTEiJ_G0020206
 protein coding gene Chr13:113869387-113880478 (-)
CBA/J MGP_CBAJ_G0020649
 protein coding gene Chr13:123728125-123735279 (-)
DBA/2J MGP_DBA2J_G0020772
 protein coding gene Chr13:110791880-110799018 (-)
FVB/NJ MGP_FVBNJ_G0020756
 protein coding gene Chr13:109488288-109503795 (-)
LP/J MGP_LPJ_G0020848
 protein coding gene Chr13:115749507-115756661 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020784
 protein coding gene Chr13:124003810-124010964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021370
 protein coding gene Chr13:113917040-113932211 (-)
PWK/PhJ MGP_PWKPhJ_G0019960
 protein coding gene Chr13:109544108-109567566 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0020264
 protein coding gene Chr13:114491596-114498750 (-)



Homology
more
  • Human Ortholog
    GZMA, granzyme A
  • Vertebrate Orthologs
    17
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMA, granzyme A
  • Synonyms
    CTLA3, HFSP
  • Links
    NCBI Gene ID: 3001
    neXtProt AC: NX_P12544
    UniProt: P12544

  • Chr Location
    5q11.2; chr5:55102646-55110252 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show normal T/NK cell-mediated cytotoxicity, recovery from LCM virus or L. monocytogenes infection, and control of syngeneic tumor growth. Homozygotes for a different null allele show defective CTL cytolysis and increased tumor burden upon challenge with RMAS cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    3
  • cDNA Data
    30
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023132 Ensembl Gene Model | MGI Sequence Detail 7157 C57BL/6J ±  kb
transcript ENSMUST00000023897 Ensembl | MGI Sequence Detail 878 Not Applicable  
polypeptide ENSMUSP00000023897 Ensembl | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 8
    cDNA 33
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10699, MGD-MRK-2223, MGD-MRK-2233, MGD-MRK-38311, MGI:2145434
References
more
  • Summaries
    All 154
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 71
  • Earliest
    J:83 Bunker LE Jr, Hepatic fusion, a new gene in linkage group I of the mouse. J Hered. 1959;50(1):40-44
  • Latest
    J:339369 Kaur G, et al., Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta cells resulting in neonatal lethality. PLoS One. 2023;18(8):e0286109
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory