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Usf2 Gene Detail
Summary
  • Symbol
    Usf2
  • Name
    upstream transcription factor 2
  • Synonyms
    bHLHb12, Usf-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99961
    NCBI Gene: 22282
  • Gene Overview
    MyGene.info: USF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:30945248-30956803 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11556 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.27 cM, cytoband A2-B1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    USF2, upstream transcription factor 2, c-fos interacting
  • Vertebrate Orthologs
    8
  • Human Ortholog
    USF2, upstream transcription factor 2, c-fos interacting
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHb12, FIP
  • Links
    NCBI Gene ID: 7392
    neXtProt AC: NX_Q15853
    UniProt: Q15853

  • Chr Location
    19q13.12; chr19:35268978-35279821 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are 20-40% smaller at birth and > 50% die postnatally, possibly because they are unable to nurse. In survivors, a proportionate dwarfism is maintained into adulthood. Males are usually infertile and die before 6 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036026 VEGA Gene Model | MGI Sequence Detail 11556 C57BL/6J ±  kb
    transcript OTTMUST00000092457 VEGA | MGI Sequence Detail 2419 Not Applicable  
    polypeptide OTTMUSP00000051103 VEGA | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      141 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
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    • All nucleic 101
      Genomic 10
      cDNA 86
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16766
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:17048 Sirito M, et al., Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 1994 Feb 11;22(3):427-33
    • Latest
      J:215612 Fernandez-Perez A, et al., Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. Biochem J. 2014 Oct 15;463(2):287-96

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory