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Usf2
Gene Detail
 Symbol
Name
ID
Usf2
upstream transcription factor 2
MGI:99961
Synonyms bHLHb12, Usf-2
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.27 cM, cytoband A2-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:30945252-30956803 bp, - strand
From VEGA annotation of GRCm38

  11552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: upstream stimulatory factor
Gene Tree: Usf2

Human
homologs
Human Homolog USF2, upstream transcription factor 2, c-fos interacting
NCBI Gene ID 7392
neXtProt AC  NX_Q15853
Human Synonyms  bHLHb12, FIP
Human Chr (Location)  19q13; chr19:35268993-35279815 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are 20-40% smaller at birth and > 50% die postnatally, possibly because they are unable to nurse. In survivors, a proportionate dwarfism is maintained into adulthood. Males are usually infertile and die before 6 months of age.
 
Interactions
Usf2 interacts with 125 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process lactation, lipid homeostasis, ...
Component nucleus
Function bHLH transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (82)    Tissues (75)    Images (19)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 72
RT-PCR 10
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) Genomic(10) cDNA(85) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036026 (Evidence)
Ensembl Gene ModelENSMUSG00000058239 (Evidence)
Entrez Gene22282 (Evidence)
UniGene322453
DFCITC1577736, TC1600767, TC1605231, TC1759413, TC1774792
NIA Mouse Gene IndexU028407, U376555
Consensus CDS ProjectCCDS21118.1
International Mouse Knockout Project StatusUsf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036026 VEGA Gene Model | MGI Sequence Detail 11552 C57BL/6J ±  kb
transcript OTTMUST00000092457 VEGA | MGI Sequence Detail 1671 Not Applicable 
polypeptide OTTMUSP00000051103 VEGA | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(8) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(203 from dbSNP Build 137)    SNPs within 2kb including multiple locations(289)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000017138 upstream stimulatory factor 2
References (Earliest) J:17048 Sirito M, et al., Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 1994 Feb 11;22(3):427-33
(Latest) J:197978 Zeng L, et al., Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells. Proteomics. 2013 Jun 10;
All references(62)
Other
accession IDs
MGD-MRK-16766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory