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Ewsr1
Gene Detail
Symbol

Name
ID
Ewsr1
Ewing sarcoma breakpoint region 1
MGI:99960
Synonyms
Ews
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.22 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:5069689-5099266 bp, - strand
From VEGA annotation of GRCm38

  29578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134632  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: RNA-binding protein, EWS type
Gene Tree: Ewsr1

Mutations,
alleles, and
phenotypes
All mutations/alleles(138) : Gene trapped(131) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.
 
Interactions
Ewsr1 interacts with 189 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component cytoplasm, membrane, ...
Function calmodulin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (110)    Tissues (84)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
Northern blot 4
Western blot 18
RT-PCR 23
cDNA source data(329)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(334) cDNA(329) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005079 (Evidence)
Ensembl Gene ModelENSMUSG00000009079 (Evidence)
Entrez Gene14030 (Evidence)
UniGene142822
DFCITC1573478, TC1592141, TC1642399, TC1675237, TC1756774
DoTSDT.101155426, DT.101285656, DT.101366616, DT.110503425, DT.535345, DT.91446568, DT.94270044, DT.94299649, DT.94299665, DT.94404073
NIA Mouse Gene IndexU032455, U151643
Consensus CDS ProjectCCDS24396.1, CCDS70131.1
International Mouse Knockout Project StatusEwsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005079 VEGA Gene Model | MGI Sequence Detail 29578 C57BL/6J ±  kb
transcript OTTMUST00000011348 VEGA | MGI Sequence Detail 2174 Not Applicable 
polypeptide OTTMUSP00000005288 VEGA | MGI Sequence Detail 661 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(21) UniProt(9)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000007243 RNA-binding protein EWS
References
(Earliest) J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
(Latest) J:204551 Park JH, et al., A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013 Aug 26;26(4):393-404
All references(55)
Other
accession IDs
MGD-MRK-16765, MGI:2146130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory