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Ewsr1 Gene Detail
Summary
  • Symbol
    Ewsr1
  • Name
    Ewing sarcoma breakpoint region 1
  • Synonyms
    Ews
  • Feature Type
    protein coding gene
  • IDs
    MGI:99960
    NCBI Gene: 14030
Location & Maps
more
  • Sequence Map
    Chr11:5069689-5099266 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.22 cM, cytoband A1-A3
  • Mapping Data
    2 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    60 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005079 VEGA Gene Model | MGI Sequence Detail 29578 C57BL/6J ±  kb
transcript OTTMUST00000011348 VEGA | MGI Sequence Detail 2174 Not Applicable  
polypeptide OTTMUSP00000005288 VEGA | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000007243 RNA-binding protein EWS
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR033109 RNA-binding protein EWS
    IPR000504 RNA recognition motif domain
    IPR001876 Zinc finger, RanBP2-type
Molecular
Reagents
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  • All nucleic 334
    cDNA 329
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16765, MGI:2146130
References
more
  • Summaries
    All 56
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 24
  • Earliest
    J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
  • Latest
    J:221663 Park JH, et al., Inactivation of EWS reduces PGC-1alpha protein stability and mitochondrial homeostasis. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6074-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory