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Ewsr1 Gene Detail
Summary
  • Symbol
    Ewsr1
  • Name
    Ewing sarcoma breakpoint region 1
  • Synonyms
    Ews
  • Feature Type
    protein coding gene
  • IDs
    MGI:99960
    NCBI Gene: 14030
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5019689-5049266 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.22 cM, cytoband A1-A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99960
 protein coding gene Chr11:5019687-5049314 (-)
129S1/SvImJ ENSMUSG00200030866
 protein coding gene Chr11:1971376-2004282 (-)
A/J ENSMUSG00195021498
 protein coding gene Chr11:1877244-1909747 (-)
AKR/J ENSMUSG00220008745
 protein coding gene Chr11:1905608-1938534 (-)
BALB/cJ ENSMUSG00180021177
 protein coding gene Chr11:1900938-1933160 (-)
C3H/HeJ ENSMUSG00175009053
 protein coding gene Chr11:1893403-1925892 (-)
C57BL/6NJ ENSMUSG00215025960
 protein coding gene Chr11:1903943-1936434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016047
 protein coding gene Chr11:1922902-1952846 (-)
CAST/EiJ ENSTCUG00005032420
 protein coding gene Chr11:1987877-2020225 (-)
CBA/J ENSMUSG00210017719
 protein coding gene Chr11:1892991-1925490 (-)
DBA/2J ENSMUSG00185016343
 protein coding gene Chr11:1990783-2023277 (-)
FVB/NJ ENSMUSG00205026022
 protein coding gene Chr11:1880782-1913703 (-)
JF1/MsJ ENSUMUG00000021081
 protein coding gene Chr11:2152558-2184533 (-)
LP/J ENSMUSG00230032208
 protein coding gene Chr11:3054482-3087381 (-)
NOD/ShiLtJ ENSMUSG00190032523
 protein coding gene Chr11:1876852-1909350 (-)
NZO/HlLtJ ENSMUSG00225025532
 protein coding gene Chr11:5112510-5145430 (-)
PWK/PhJ ENSLUMG00010017526
 protein coding gene Chr11:1887260-1919756 (-)
SPRET/EiJ ENSMSPG00010007261
 protein coding gene Chr11:1969188-2000504 (-)
WSB/EiJ ENSIUOG00005007268
 protein coding gene Chr11:1897811-1930710 (-)



Homology
more
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
  • Synonyms
    EWS, EWS-FLI1
  • Links
    NCBI Gene ID: 2130
    UniProt: Q01844

  • Chr Location
    22q12.2; chr22:29268009-29300530 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EWSR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    115
  • cDNA Data
    330
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009079 Ensembl Gene Model | MGI Sequence Detail 29578 C57BL/6J ±  kb
    transcript ENSMUST00000102930 Ensembl | MGI Sequence Detail 2174 Not Applicable  
    polypeptide ENSMUSP00000099994 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 339
      cDNA 330
      Primer pair 7
      Other 2
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16765, MGI:2146130
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 16
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory