Ewsr1
Gene Detail

Symbol Name ID

Ewsr1 Ewing sarcoma breakpoint region 1 MGI:99960

Synonyms

Ews

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.22 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:5069689-5099266 bp, - strand From VEGA annotation of GRCm38   29578 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RNA-binding protein, EWS type
Gene Tree: Ewsr1

Human homologs

Human Homolog		EWSR1, Ewing sarcoma breakpoint region 1
NCBI Gene ID		2130
neXtProt AC		NX_Q01844
Human Synonyms		bK984G1.4, EWS
Human Chr (Location)		22q12.2; chr22:29663998-29696515 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EWSR1

Alleles and phenotypes

All alleles(136) : Targeted(5) Gene trapped(131)
 

Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	regulation of transcription, DNA-dependent, transcription, DNA-dependent
Component	Cajal body, cytoplasm, ...
Function	calmodulin binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (110)    Tissues (80)    Images (8)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	65
Northern blot	4
Western blot	18
RT-PCR	23

cDNA source data(329)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(334) cDNA(329) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005079 (Evidence)
Ensembl Gene Model	ENSMUSG00000009079 (Evidence)
Entrez Gene	14030 (Evidence)
UniGene	142822
DFCI	TC1573478, TC1592141, TC1642399, TC1756774
DoTS	DT.101155426, DT.101285656, DT.101366616, DT.110503425, DT.535345, DT.91446568, DT.94270044, DT.94404073
NIA Mouse Gene Index	U032455, U151643
Consensus CDS Project	CCDS24396.1
International Mouse Knockout Project Status	Ewsr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005079	VEGA Gene Model | MGI Sequence Detail	29578	C57BL/6J
transcript	OTTMUST00000011348	VEGA | MGI Sequence Detail	2174	Not Applicable
polypeptide	OTTMUSP00000005288	VEGA | MGI Sequence Detail	661	Not Applicable

All sequences(83) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR001876	Zinc finger, RanBP2-type
Protein Ontology	PR:000007243	RNA-binding protein EWS

References

(Earliest) J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
(Latest) J:188129 Sohn EJ, et al., Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. Biochem Biophys Res Commun. 2012 Sep 14;426(1):89-93
All references(54)

Other accession IDs

MGD-MRK-16765, MGI:2146130