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Mafk Gene Detail
Summary
  • Symbol
    Mafk
  • Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
  • Synonyms
    NF-E2, Nfe2u, p18 NF-E2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99951
    NCBI Gene: 17135
  • Gene Overview
    MyGene.info: MAFK
Location & Maps
more
  • Sequence Map
    Chr5:139791513-139802653 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11141 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.81 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    MAFK, MAF bZIP transcription factor K
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAFK, MAF bZIP transcription factor K
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NFE2U, P18
  • Links
    NCBI Gene ID: 7975
    neXtProt AC: NX_O60675

  • Chr Location
    7p22.3; chr7:1530732-1543043 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    16 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    1
  • Targeted
    5
  • Transgenic
    2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele are viable, fertile, healthy and phenotypically normal with no detectable erythroid deficiencies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025256 VEGA Gene Model | MGI Sequence Detail 11141 C57BL/6J ±  kb
transcript OTTMUST00000062176 VEGA | MGI Sequence Detail 2849 Not Applicable  
polypeptide OTTMUSP00000030611 VEGA | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    82 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010051 transcription factor MafK
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR024874 Transcription factor Maf family
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 56
    Genomic 4
    cDNA 45
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12104, MGD-MRK-16754, MGI:2141147
References
more
  • Summaries
    All 60
    Developmental Gene Expression 12
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:20799 Andrews NC, et al., The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92
  • Latest
    J:207849 Hwang YJ, et al., MafK positively regulates NF-kappaB activity by enhancing CBP-mediated p65 acetylation. Sci Rep. 2013;3:3242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory