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Mafk
Gene Detail
Symbol

Name
ID
Mafk
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
MGI:99951
Synonyms
NF-E2, Nfe2u, p18 NF-E2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
78.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:139791513-139802653 bp, + strand
From VEGA annotation of GRCm38

  11141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor MafK
Gene Tree: Mafk

Human
homologs
Human Homolog MAFK, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
NCBI Gene ID 7975
neXtProt AC  NX_O60675
Human Synonyms  NFE2U, P18
Human Chr (Location)  7p22.3; chr7:1530732-1543043 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele are viable, fertile, healthy and phenotypically normal with no detectable erythroid deficiencies.
 
Interactions
Mafk interacts with 229 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process nervous system development, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (141)    Tissues (92)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
In situ reporter (knock in) 11
Northern blot 13
Western blot 2
RT-PCR 37
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(4) cDNA(45) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025256 (Evidence)
Ensembl Gene ModelENSMUSG00000018143 (Evidence)
Entrez Gene17135 (Evidence)
UniGene157313
DFCITC1578869
DoTSDT.486791
NIA Mouse Gene IndexU006367
Consensus CDS ProjectCCDS19814.1
International Mouse Knockout Project StatusMafk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025256 VEGA Gene Model | MGI Sequence Detail 11141 C57BL/6J ±  kb
transcript OTTMUST00000062176 VEGA | MGI Sequence Detail 2849 Not Applicable 
polypeptide OTTMUSP00000030611 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010051 transcription factor MafK
References
(Earliest) J:20799 Andrews NC, et al., The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92
(Latest) J:204483 Fujita R, et al., NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013 Jul;33(14):2659-70
All references(61)
Other
accession IDs
MGD-MRK-12104, MGD-MRK-16754, MGI:2141147

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory