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Mybl1
Gene Detail
Symbol

Name
ID
Mybl1
myeloblastosis oncogene-like 1
MGI:99925
Synonyms
A-myb, G1-419-6, repro9
Feature Type
protein coding gene
Genetic Map
Chromosome 1
2.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:9667415-9700209 bp, - strand
From VEGA annotation of GRCm38

  32795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Myb transforming protein
Gene Tree: Mybl1

Human
homologs
Human Homolog MYBL1, v-myb avian myeloblastosis viral oncogene homolog-like 1
NCBI Gene ID 4603
neXtProt AC  NX_P10243
Human Synonyms  AMYB, A-MYB
Human Chr (Location)  8q13.1; chr8:66562175-66613249 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.
 
Interactions
Mybl1 interacts with 396 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (186)    Tissues (154)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 178
RT-PCR 8
cDNA source data(23)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034736 (Evidence)
Ensembl Gene ModelENSMUSG00000025912 (Evidence)
Entrez Gene17864 (Evidence)
DFCITC1586442, TC1612430
DoTSDT.40185595, DT.55283294
NIA Mouse Gene IndexU021111, U361027
Consensus CDS ProjectCCDS35510.1, CCDS69861.1
International Mouse Knockout Project StatusMybl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034736 VEGA Gene Model | MGI Sequence Detail 32795 C57BL/6J ±  kb
transcript OTTMUST00000088260 VEGA | MGI Sequence Detail 4980 Not Applicable 
polypeptide OTTMUSP00000048087 VEGA | MGI Sequence Detail 751 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015395 C-myb, C-terminal
InterPro IPR009057 Homeodomain-like
InterPro IPR017930 Myb domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR012642 Transcription regulator Wos2-domain
Protein Ontology PR:000010801 myb-related protein A
References
(Earliest) J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
(Latest) J:202012 Pandey RR, et al., Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
All references(51)
Other
accession IDs
MGD-MRK-16727, MGI:3512779

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory