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Mybl1 Gene Detail
Summary
  • Symbol
    Mybl1
  • Name
    myeloblastosis oncogene-like 1
  • Synonyms
    A-myb, G1-419-6, repro9
  • Feature Type
    protein coding gene
  • IDs
    MGI:99925
    NCBI Gene: 17864
Location & Maps
more
  • Genetic Map
    Chromosome 1, 2.08 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MYBL1, MYB proto-oncogene like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYBL1, MYB proto-oncogene like 1
    Orthology source: HomoloGene
  • Synonyms
    AMYB, A-MYB
  • Links
    NCBI Gene ID: 4603
    neXtProt AC: NX_P10243

  • Chr Location
    8q13.1; chr8:66562175-66613249 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Gene trapped
    5
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034736 VEGA Gene Model | MGI Sequence Detail 32795 C57BL/6J ±  kb
transcript OTTMUST00000088260 VEGA | MGI Sequence Detail 4980 Not Applicable  
polypeptide OTTMUSP00000048087 VEGA | MGI Sequence Detail 751 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    183 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 26
    Genomic 1
    cDNA 23
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16727, MGI:3512779
References
more
  • Summaries
    All 49
    Developmental Gene Expression 14
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
  • Latest
    J:227136 Shawlot W, et al., Rfx2 is required for spermatogenesis in the mouse. Genesis. 2015 Aug 6;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory