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Mybl1
Gene Detail
Symbol

Name
ID
Mybl1
myeloblastosis oncogene-like 1
MGI:99925
Synonyms
A-myb, G1-419-6, repro9
Feature Type
protein coding gene
Genetic Map
Chromosome 1
2.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:9667415-9700209 bp, - strand
From VEGA annotation of GRCm38

  32795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYBL1
Protein SuperFamily: Myb transforming protein
Gene Tree: Mybl1

Human
homologs
MYBL1, v-myb avian myeloblastosis viral oncogene homolog-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4603
neXtProt AC: NX_P10243

Human Synonyms: AMYB, A-MYB

Human Chr (Location): 8q13.1; chr8:66562175-66613249 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.
 
Interactions
Mybl1 interacts with 395 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (13 records)
Data Summary: Results (186)    Tissues (154)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 178
RT-PCR 8
cDNA source data(23)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase mybl1 ; ZFIN mybl1    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034736 (Evidence)
Ensembl Gene Model ENSMUSG00000025912 (Evidence)
Entrez Gene 17864 (Evidence)
DFCI TC1586442, TC1612430
DoTS DT.40185595, DT.55283294
NIA Mouse Gene Index U021111, U361027
Consensus CDS Project CCDS35510.1, CCDS69861.1
International Mouse Phenotyping Consortium Status Mybl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034736 VEGA Gene Model | MGI Sequence Detail 32795 C57BL/6J ±  kb
transcript OTTMUST00000088260 VEGA | MGI Sequence Detail 4980 Not Applicable 
polypeptide OTTMUSP00000048087 VEGA | MGI Sequence Detail 751 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015395 C-myb, C-terminal
InterPro IPR009057 Homeodomain-like
InterPro IPR017930 Myb domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR012642 Transcription regulator Wos2-domain
Protein Ontology PR:000010801 myb-related protein A
References
(Earliest) J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
(Latest) J:214809 Moniot B, et al., Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
All references(51)
Other
accession IDs
MGD-MRK-16727, MGI:3512779

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory