Mybl1 MGI Mouse Gene Detail - MGI:99925 - Myb proto-oncogene like 1

Symbol

Mybl1
Name

Myb proto-oncogene like 1
Synonyms

A-myb, G1-419-6, repro9

Feature Type

protein coding gene
IDs

MGI:99925
NCBI Gene: 17864
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:9737640-9770434 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 2.08 cM
Mapping Data

3 experiments

SNPs within 2kb

634 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99925	protein coding gene	Chr1:9737632-9770664 (-)
129S1/SvImJ	ENSMUSG00200002187	protein coding gene	Chr1:7059567-7092340 (-)
A/J	ENSMUSG00195002671	protein coding gene	Chr1:6877288-6910062 (-)
AKR/J	ENSMUSG00220003056	protein coding gene	Chr1:6977671-7010443 (-)
BALB/cJ	ENSMUSG00180008386	protein coding gene	Chr1:6960867-6993641 (-)
C3H/HeJ	ENSMUSG00175000068	protein coding gene	Chr1:6842651-6875439 (-)
C57BL/6NJ	ENSMUSG00215004060	protein coding gene	Chr1:6922031-6954828 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013939	protein coding gene	Chr1:5827854-5860577 (-)
CAST/EiJ	ENSTCUG00005001945	protein coding gene	Chr1:7299820-7332610 (-)
CBA/J	ENSMUSG00210001561	protein coding gene	Chr1:6702150-6734937 (-)
DBA/2J	ENSMUSG00185004134	protein coding gene	Chr1:7799002-7831802 (-)
FVB/NJ	ENSMUSG00205005094	protein coding gene	Chr1:7054649-7087423 (-)
JF1/MsJ	ENSUMUG00000003154	protein coding gene	Chr1:7087082-7119907 (-)
LP/J	ENSMUSG00230002120	protein coding gene	Chr1:7801282-7834054 (-)
NOD/ShiLtJ	ENSMUSG00190001126	protein coding gene	Chr1:6854350-6887124 (-)
NZO/HlLtJ	ENSMUSG00225005123	protein coding gene	Chr1:11203250-11236022 (-)
PWK/PhJ	ENSLUMG00010002239	protein coding gene	Chr1:6692411-6725202 (-)
SPRET/EiJ	ENSMSPG00010013751	protein coding gene	Chr1:7287496-7320201 (-)
WSB/EiJ	ENSIUOG00005011009	protein coding gene	Chr1:6880594-6913371 (-)

Human Ortholog

MYBL1, MYB proto-oncogene like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYBL1, MYB proto-oncogene like 1
Synonyms

A-MYB, AMYB
Links

HGNC:7547

NCBI Gene ID: 4603

UniProt: P10243
Chr Location

8q13.1; chr8:66562175-66614247 (-) GRCh38

MGI Vertebrate Homology

Mybl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYBL1
Gene Tree

Mybl1

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Phenotype Summary

37 phenotypes from 3 alleles in 4 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

5
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

215
cDNA Data

26
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mybl1

ZFIN mybl1

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All Sequences

52
RefSeq

10
UniProt

6
CCDS

CCDS35510.1, CCDS69861.1

Ensembl

ENSMUSG00000025912 (Evidence)
NCBI Gene

17864

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025912	Ensembl Gene Model \| MGI Sequence Detail	32795	C57BL/6J	± kb
transcript	ENSMUST00000088658	Ensembl \| MGI Sequence Detail	4980	Not Applicable
polypeptide	ENSMUSP00000086034	Ensembl \| MGI Sequence Detail	751	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010801 Myb-related protein A

(term hierarchy)
InterPro Domains

IPR015395 C-myb, C-terminal

IPR009057 Homeodomain-like superfamily

IPR017930 Myb domain

IPR001005 SANT/Myb domain

IPR050560 Transcription factors Myb-like

IPR012642 Transcription regulator Wos2-domain

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All nucleic 33

Genomic 1

cDNA 27

Primer pair 4

Other 1

Antibodies 1

Microarray probesets 4

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MGD-MRK-16727, MGI:3512779

Summaries

All 65

Developmental Gene Expression 16

Gene Ontology 9

Phenotypes 23
Earliest

J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
Latest

J:363995 Kitamura Y, et al., CTCF-mediated 3D chromatin sets up the gene expression program in the male germline. Nat Struct Mol Biol. 2025 Mar 3;

TSS for Mybl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10929	Chr1:9770618-9770637 (-)	-194 bp
Tssr10928	Chr1:9770568-9770611 (-)	-156 bp
Tssr10927	Chr1:9770542-9770554 (-)	-114 bp
Tssr10926	Chr1:9767088-9767099 (-)	3,340 bp
Tssr10925	Chr1:9755760-9755764 (-)	14,672 bp
Tssr10924	Chr1:9752431-9752433 (-)	18,002 bp
Tssr10923	Chr1:9737925-9737926 (-)	32,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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