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Pyy
Gene Detail
 Symbol
Name
ID
Pyy
peptide YY
MGI:99924
Synonyms MGC:19143
Feature Type protein coding gene
Genetic Map
Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:102106676-102107832 bp, - strand
From VEGA annotation of GRCm38

  1157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Pyy

Human
homologs
Human Homolog PYY, peptide YY
NCBI Gene ID 5697
neXtProt AC  NX_P10082
Human Synonyms  PYY1, PYY-I
Human Chr (Location)  17q21.1; chr17:43952738-44004469 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PYY
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Mice homozygous for one null mutation showed normal growth, food intake, and energy expenditure. Mice homozygous for another null allele exhibit polyphagia, increased adipose tissue and are resistant to the benefits of a high-protein diet.
 
Phenotype Images(1)
Interactions
Pyy interacts with 31 markers (Mir129-1, Mir129-2, Mir210, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process eating behavior, negative regulation of response to food
Component extracellular region, extracellular space
Function hormone activity, neuropeptide hormone activity
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (30)    Tissues (11)    Images (26)
Theiler Stages: 12, 13, 14, 15, 22, 23
Assay TypeResults
Immunohistochemistry 1
RNA in situ 27
RT-PCR 2
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002320 (Evidence)
Ensembl Gene ModelENSMUSG00000017311 (Evidence)
Entrez Gene217212 (Evidence)
UniGene46248
DFCITC1584387
DoTSDT.101229311, DT.528740
NIA Mouse Gene IndexU033467
Consensus CDS ProjectCCDS36339.1
International Mouse Knockout Project StatusPyy
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002320 VEGA Gene Model | MGI Sequence Detail 1157 C57BL/6J ±  kb
transcript OTTMUST00000104250 VEGA | MGI Sequence Detail 551 Not Applicable 
polypeptide OTTMUSP00000058324 VEGA | MGI Sequence Detail 100 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001955 Pancreatic hormone-like
InterPro IPR020392 Pancreatic hormone-like, conserved site
Protein Ontology PR:000013526 peptide YY
References (Earliest) J:16874 Upchurch BH, et al., Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb;120(2):245-52
(Latest) J:198627 Engert S, et al., Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013 Aug;140(15):3128-38
All references(56)
Other
accession IDs
MGD-MRK-16726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory