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Pyy
Gene Detail
Symbol

Name
ID
Pyy
peptide YY
MGI:99924
Synonyms
MGC:19143
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:102106676-102107832 bp, - strand
From VEGA annotation of GRCm38

  1157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PYY
Gene Tree: Pyy

Human
homologs
PYY, peptide YY
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5697
neXtProt AC: NX_P10082

Human Synonyms: PYY1, PYY-I

Human Chr (Location): 17q21.1; chr17:43952733-44024260 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Pyy (1)
 
Mice homozygous for one null mutation showed normal growth, food intake, and energy expenditure. Mice homozygous for another null allele exhibit polyphagia, increased adipose tissue and are resistant to the benefits of a high-protein diet.
 
Phenotype Images(2)
Interactions
Pyy interacts with 31 markers (Mir129-1, Mir129-2, Mir210, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell-cell signaling, digestion, ...
Component extracellular region, extracellular space
Function G-protein coupled receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (30)    Tissues (11)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 27
RT-PCR 2
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pyy ; ZFIN pyya, pyyb    NEW 
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002320 (Evidence)
Ensembl Gene Model ENSMUSG00000017311 (Evidence)
Entrez Gene 217212 (Evidence)
UniGene 46248
DFCI TC1584387
DoTS DT.101229311, DT.528740
NIA Mouse Gene Index U033467
Consensus CDS Project CCDS36339.1
International Mouse Phenotyping Consortium Status Pyy
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002320 VEGA Gene Model | MGI Sequence Detail 1157 C57BL/6J ±  kb
transcript OTTMUST00000104250 VEGA | MGI Sequence Detail 551 Not Applicable 
polypeptide OTTMUSP00000058324 VEGA | MGI Sequence Detail 100 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001955 Pancreatic hormone-like
InterPro IPR020392 Pancreatic hormone-like, conserved site
Protein Ontology PR:000013526 peptide YY
References
(Earliest) J:16874 Upchurch BH, et al., Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb;120(2):245-52
(Latest) J:218509 Kim HJ, et al., Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
All references(59)
Other
accession IDs
MGD-MRK-16726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory