Pyy
Gene Detail

Symbol Name ID

Pyy peptide YY MGI:99924

Synonyms

MGC:19143

Feature Type

protein coding gene

Genetic Map

Chromosome 11

65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:102106676-102107832 bp, - strand From VEGA annotation of GRCm38   1157 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Pyy

Human homologs

Human Homolog		PYY, peptide YY
NCBI Gene ID		5697
neXtProt AC		NX_P10082
Human Synonyms		PYY1, PYY-I
Human Chr (Location)		17q21.1; chr17:42030106-42081837 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PYY

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for one null mutation showed normal growth, food intake, and energy expenditure. Mice homozygous for another null allele exhibit polyphagia, increased adipose tissue and are resistant to the benefits of a high-protein diet.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	eating behavior, negative regulation of response to food
Component	extracellular region, extracellular space
Function	hormone activity, neuropeptide hormone activity

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (30)    Tissues (11)    Images (26)
Theiler Stages: 12, 13, 14, 15, 22, 23

Assay Type	Results
Immunohistochemistry	1
RNA in situ	27
RT-PCR	2

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002320 (Evidence)
Ensembl Gene Model	ENSMUSG00000017311 (Evidence)
Entrez Gene	217212 (Evidence)
UniGene	46248
DFCI	TC1584387
DoTS	DT.101229311, DT.528740
NIA Mouse Gene Index	U033467
Consensus CDS Project	CCDS36339.1
International Mouse Knockout Project Status	Pyy

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002320	VEGA Gene Model | MGI Sequence Detail	1157	C57BL/6J
transcript	OTTMUST00000104250	VEGA | MGI Sequence Detail	551	Not Applicable
polypeptide	OTTMUSP00000058324	VEGA | MGI Sequence Detail	100	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001955	Pancreatic hormone-like
InterPro	IPR020392	Pancreatic hormone-like, conserved site
Protein Ontology	PR:000013526	peptide YY

References

(Earliest) J:16874 Upchurch BH, et al., Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb;120(2):245-52
(Latest) J:189527 De Jonghe BC, et al., Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51
All references(53)

Other accession IDs

MGD-MRK-16726