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Kcnma1
Gene Detail
Symbol

Name
ID
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923
Synonyms
5730414M22Rik, BKCa, BK channel alpha subunit, MaxiK, mSlo1, Slo, Slo1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
12.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:23299381-24004859 bp, - strand
From VEGA annotation of GRCm38

  705479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calcium-activated potassium channel, alpha subunit
Gene Tree: Kcnma1

Human
homologs
Human Homolog KCNMA1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
NCBI Gene ID 3778
neXtProt AC  NX_Q12791
Human Synonyms  bA205K10.1, BKTM, KCa1.1, MaxiK, mSLO1, SAKCA, SLO, SLO1, SLO-ALPHA
Human Chr (Location)  10q22.3; chr10:76869601-77637819 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNMA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to cerebellar ataxia, Purkinje cell dysfunction, uneven gait patterns, bladder hyperactivity, urinary incontinence, abnormal colonic K+ secretion, and hearing impairment.
 
Interactions
Kcnma1 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (263)    Tissues (58)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 263
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(30) Primer pair(12) Other(6)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045153 VEGA Gene Model | MGI Sequence Detail 705479 C57BL/6J ±  kb
transcript OTTMUST00000118654 VEGA | MGI Sequence Detail 4440 Not Applicable 
polypeptide OTTMUSP00000066221 VEGA | MGI Sequence Detail 1239 Not Applicable 

For the selected sequences
All sequences(303) RefSeq(100) UniProt(81)
Polymorphisms
SNPs within 2kb(3713 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008981 F-MuLV receptor-binding
InterPro IPR005821 Ion transport domain
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
InterPro IPR003148 Regulator of K+ conductance, N-terminal
InterPro IPR018154 TLV/ENV coat polyprotein
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000001849 calcium-activated potassium channel subunit alpha-1
References
(Earliest) J:13395 Butler A, et al., mSlo, a complex mouse gene encoding maxi calcium-activated potassium channels. Science. 1993 Jul 9;261(5118):221-4
(Latest) J:207964 Pan NC, et al., Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014 Mar 28;446(1):316-21
All references(104)
Other
accession IDs
MGD-MRK-16725, MGI:1917778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory