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Kcnma1
Gene Detail
 Symbol
Name
ID
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923
Synonyms 5730414M22Rik, BKCa, BK channel alpha subunit, MaxiK, mSlo1, Slo, Slo1
Feature Type protein coding gene
Genetic Map
Chromosome 14
12.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:23289431-23803304 bp, - strand
From Ensembl annotation of GRCm38

  513874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: calcium-activated potassium channel, alpha subunit
Gene Tree: Kcnma1

Human
homologs
Human Homolog KCNMA1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
NCBI Gene ID 3778
neXtProt AC  NX_Q12791
Human Synonyms  bA205K10.1, BKTM, KCa1.1, MaxiK, mSLO1, SAKCA, SLO, SLO1, SLO-ALPHA
Human Chr (Location)  10q22.3; chr10:76869601-77637819 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNMA1
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Homozygous inactivation of this gene leads to cerebellar ataxia, Purkinje cell dysfunction, uneven gait patterns, bladder hyperactivity, urinary incontinence, abnormal colonic K+ secretion, and hearing impairment.
 
Gene Ontology
(GO)
classifications
All GO classifications: (101 annotations)
Process adult walking behavior, auditory receptor cell differentiation, ...
Component apical plasma membrane, caveola, ...
Function actin binding, calcium-activated potassium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (263)    Tissues (57)    Images (7)
Theiler Stages: 13, 15, 20, 23, 25, 26, 28
Assay TypeResults
RT-PCR 263
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(48) cDNA(30) Primer pair(12) Other(6)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000063142 (Evidence)
Entrez Gene16531 (Evidence)
DFCITC1587327, TC1603356, TC1632404, TC1645762, TC1686415, TC1692989, TC1709717
DoTSDT.101238755, DT.101370054, DT.110745312, DT.55163404, DT.55193524, DT.91333452, DT.91336653, DT.91420676, DT.94182500, DT.94236349, DT.97349999, DT.97361262
NIA Mouse Gene IndexU035306, U236031, U256017
International Mouse Knockout Project StatusKcnma1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063142 Ensembl Gene Model | MGI Sequence Detail 513874 C57BL/6J ±  kb
transcript ENSMUST00000177634 Ensembl | MGI Sequence Detail 4605 Not Applicable 
polypeptide ENSMUSP00000136447 Ensembl | MGI Sequence Detail 1135 Not Applicable 

For the selected sequences
All sequences(234) RefSeq(100) UniProt(38)
Polymorphisms SNPs within 2kb(3762 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024939 Calcium-activated potassium channel Slo
InterPro IPR008981 F-MuLV receptor-binding
InterPro IPR005821 Ion transport domain
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
InterPro IPR003148 Regulator of K+ conductance, N-terminal
InterPro IPR018154 TLV/ENV coat polyprotein
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000001849 calcium-activated potassium channel subunit alpha-1
References (Earliest) J:13395 Butler A, et al., mSlo, a complex mouse gene encoding maxi calcium-activated potassium channels. Science. 1993 Jul 9;261(5118):221-4
(Latest) J:201018 Wojtovich AP, et al., A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel. PeerJ. 2013;1:e48
All references(100)
Other
accession IDs
MGD-MRK-16725, MGI:1917778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory