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Kcnma1
Gene Detail
 Symbol
Name
ID
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923
Synonyms 5730414M22Rik, BKCa, BK channel alpha subunit, MaxiK, mSlo1, Slo, Slo1
Feature Type protein coding gene
Genetic Map
Chromosome 14
12.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:23299381-24004859 bp, - strand
From VEGA annotation of GRCm38

  705479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calcium-activated potassium channel, alpha subunit
Gene Tree: Kcnma1

Human
homologs
Human Homolog KCNMA1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
NCBI Gene ID 3778
neXtProt AC  NX_Q12791
Human Synonyms  bA205K10.1, BKTM, KCa1.1, MaxiK, mSLO1, SAKCA, SLO, SLO1, SLO-ALPHA
Human Chr (Location)  10q22.3; chr10:76869601-77637819 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNMA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to cerebellar ataxia, Purkinje cell dysfunction, uneven gait patterns, bladder hyperactivity, urinary incontinence, abnormal colonic K+ secretion, and hearing impairment.
 
Interactions
Kcnma1 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (104 annotations)
Process adult walking behavior, auditory receptor cell differentiation, ...
Component apical plasma membrane, caveola, ...
Function actin binding, calcium-activated potassium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (263)    Tissues (57)    Images (7)
Theiler Stages: 13, 15, 20, 23, 25, 26, 28
Assay TypeResults
RT-PCR 263
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(30) Primer pair(12) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000045153 (Evidence)
Ensembl Gene ModelENSMUSG00000063142 (Evidence)
Entrez Gene16531 (Evidence)
DFCITC1587327, TC1603356, TC1632404, TC1645762, TC1686415, TC1692989, TC1709717
DoTSDT.101238755, DT.101370054, DT.110745312, DT.55163404, DT.55193524, DT.91333452, DT.91336653, DT.91420676, DT.94182500, DT.94236349, DT.97349999, DT.97361262
NIA Mouse Gene IndexU035306, U236031, U256017
International Mouse Knockout Project StatusKcnma1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045153 VEGA Gene Model | MGI Sequence Detail 705479 C57BL/6J ±  kb
transcript OTTMUST00000118654 VEGA | MGI Sequence Detail 4440 Not Applicable 
polypeptide OTTMUSP00000066221 VEGA | MGI Sequence Detail 1239 Not Applicable 

For the selected sequences
All sequences(248) RefSeq(100) UniProt(38)
Polymorphisms SNPs within 2kb(3713 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008981 F-MuLV receptor-binding
InterPro IPR005821 Ion transport domain
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
InterPro IPR003148 Regulator of K+ conductance, N-terminal
InterPro IPR018154 TLV/ENV coat polyprotein
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000001849 calcium-activated potassium channel subunit alpha-1
References (Earliest) J:13395 Butler A, et al., mSlo, a complex mouse gene encoding maxi calcium-activated potassium channels. Science. 1993 Jul 9;261(5118):221-4
(Latest) J:207964 Pan NC, et al., Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014 Mar 28;446(1):316-21
All references(104)
Other
accession IDs
MGD-MRK-16725, MGI:1917778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory