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Lamb3
Gene Detail
 Symbol
Name
ID
Lamb3
laminin, beta 3
MGI:99915
Synonyms nicein, 125kDa
Feature Type protein coding gene
Genetic Map
Chromosome 1
97.71 cM, cytoband H2-H6
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:193301957-193343878 bp, + strand
From VEGA annotation of GRCm38

  41922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Lamb3

Human
homologs
Human Homolog LAMB3, laminin, beta 3
NCBI Gene ID 3914
neXtProt AC  NX_Q13751
Human Synonyms  BM600-125KDA, LAM5, LAMNB1
Human Chr (Location)  1q32; chr1:209614870-209652475 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LAMB3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous intracisternal A particle sequence insertion exhibit blistering of the skin and mucosal surfaces with abnormal hemidesmosomes. Mutants die neonatally, usually without feeding.
 
Human Diseases Modeled Using Mouse Lamb3 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Lamb3 interacts with 75 markers (Mir24-1, Mir24-2, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process brown fat cell differentiation, cell adhesion
Component basement membrane, extracellular region, ...
Function protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (141)    Tissues (85)    Images (39)
Theiler Stages: 11, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 79
RT-PCR 49
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025453 (Evidence)
Ensembl Gene ModelENSMUSG00000026639 (Evidence)
Entrez Gene16780 (Evidence)
UniGene435441
DFCITC1581446
DoTSDT.101353715, DT.101704752, DT.482235, DT.55166867
Consensus CDS ProjectCCDS15637.1
International Mouse Knockout Project StatusLamb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025453 VEGA Gene Model | MGI Sequence Detail 41922 C57BL/6J ±  kb
transcript OTTMUST00000062678 VEGA | MGI Sequence Detail 4092 Not Applicable 
polypeptide OTTMUSP00000030940 VEGA | MGI Sequence Detail 1168 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(441 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009656 laminin subunit beta-3
References (Earliest) J:13948 Karn RC, Tcp changed to Abp. Mouse News Lett. 1983;69:25
(Latest) J:187983 Lopez-Escobar B, et al., Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling. Dev Dyn. 2012 Nov;241(11):1808-15
All references(58)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory