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Lamb3 Gene Detail
Summary
  • Symbol
    Lamb3
  • Name
    laminin, beta 3
  • Synonyms
    nicein, 125kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:99915
    NCBI Gene: 16780
Location & Maps
more
  • Sequence Map
    Chr1:193207699-193343878 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      136180 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 97.71 cM, cytoband H2-H6
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LAMB3, laminin subunit beta 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LAMB3, laminin subunit beta 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI1A, BM600-125KDA, LAM5, LAMNB1
  • Links
    NCBI Gene ID: 3914
    neXtProt AC: NX_Q13751

  • Chr Location
    1q32.2; chr1:209614870-209652475 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 191
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LAMB3
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Lamb3 mouse models; 3 with human LAMB3 associations

Human Disease Mouse Models
       Epidermolysis Bullosa, Junctional, Herlitz Type   OMIM: 226700 View 2 models
Epidermolysis Bullosa, Junctional, Non-Herlitz Type   OMIM: 226650 View 1 model
       Amelogenesis Imperfecta, Type IA; AI1A   OMIM: 104530
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    6
  • Incidental Mutations
Homozygotes for a spontaneous intracisternal A particle sequence insertion exhibit blistering of the skin and mucosal surfaces with abnormal hemidesmosomes. Mutants die neonatally, usually without feeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025453 VEGA Gene Model | MGI Sequence Detail 136180 C57BL/6J ±  kb
transcript OTTMUST00000128862 VEGA | MGI Sequence Detail 4867 Not Applicable  
polypeptide OTTMUSP00000069296 VEGA | MGI Sequence Detail 1168 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1170 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 39
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16713
References
more
  • Summaries
    All 62
    Developmental Gene Expression 31
    Diseases 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:13948 Karn RC, Tcp changed to Abp. Mouse News Lett. 1983;69:25
  • Latest
    J:235682 Villacorte M, et al., Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory