Lamb3
Gene Detail

Symbol Name ID

Lamb3 laminin, beta 3 MGI:99915

Synonyms

nicein, 125kDa

Feature Type

protein coding gene

Genetic Map

Chromosome 1

97.71 cM, cytoband H2-H6
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:193301957-193343878 bp, + strand From VEGA annotation of GRCm38   41922 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Lamb3

Human homologs

Human Homolog		LAMB3, laminin, beta 3
NCBI Gene ID		3914
neXtProt AC		NX_Q13751
Human Synonyms		BM600-125KDA, LAM5, LAMNB1
Human Chr (Location)		1q32; chr1:209788215-209825820 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LAMB3

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(1) Spontaneous(1)
 

Homozygotes for a spontaneous intracisternal A particle sequence insertion exhibit blistering of the skin and mucosal surfaces with abnormal hemidesmosomes. Mutants die neonatally, usually without feeding.

 
Human Diseases Modeled Using Mouse Lamb3 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	brown fat cell differentiation, cell adhesion
Component	basement membrane, extracellular region, ...
Function	protein complex binding

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (141)    Tissues (85)    Images (39)
Theiler Stages: 11, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	79
RT-PCR	49

cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025453 (Evidence)
Ensembl Gene Model	ENSMUSG00000026639 (Evidence)
Entrez Gene	16780 (Evidence)
UniGene	435441
DFCI	TC1581446
DoTS	DT.101353715, DT.101704752, DT.482235, DT.55166867
Consensus CDS Project	CCDS15637.1
International Mouse Knockout Project Status	Lamb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025453	VEGA Gene Model | MGI Sequence Detail	41922	C57BL/6J
transcript	OTTMUST00000062678	VEGA | MGI Sequence Detail	4092	Not Applicable
polypeptide	OTTMUSP00000030940	VEGA | MGI Sequence Detail	1168	Not Applicable

All sequences(39) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(319 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009656	laminin subunit beta-3

References

(Earliest) J:13948 Karn RC, Tcp changed to Abp. Mouse News Lett. 1983;69:25
(Latest) J:187983 Lopez-Escobar B, et al., Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling. Dev Dyn. 2012 Nov;241(11):1808-15
All references(56)

Other accession IDs

MGD-MRK-16713