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Lamb3
Gene Detail
Symbol

Name
ID
Lamb3
laminin, beta 3
MGI:99915
Synonyms
nicein, 125kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.71 cM, cytoband H2-H6
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:193207699-193343878 bp, + strand
From VEGA annotation of GRCm38

  136180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: LAMB3
Gene Tree: Lamb3

Human
homologs
LAMB3, laminin, beta 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3914
neXtProt AC: NX_Q13751

Human Synonyms: AI1A, BM600-125KDA, LAM5, LAMNB1

Human Chr (Location): 1q32; chr1:209614870-209652475 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human LAMB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous intracisternal A particle sequence insertion exhibit blistering of the skin and mucosal surfaces with abnormal hemidesmosomes. Mutants die neonatally, usually without feeding.
 
Human Diseases Modeled in Mice Using Lamb3 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Lamb3 interacts with 75 markers (Mir24-1, Mir24-2, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process brown fat cell differentiation, cell adhesion
Component basement membrane, extracellular region, ...
Function protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (149)    Tissues (93)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 79
RT-PCR 51
cDNA source data(38)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lamb3    NEW 
Molecular
reagents
All nucleic(43) cDNA(39) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025453 (Evidence)
Ensembl Gene Model ENSMUSG00000026639 (Evidence)
Entrez Gene 16780 (Evidence)
UniGene 435441
DFCI TC1581446
DoTS DT.101353715, DT.101704752, DT.482235, DT.55166867
Consensus CDS Project CCDS15637.1
International Mouse Phenotyping Consortium Status Lamb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025453 VEGA Gene Model | MGI Sequence Detail 136180 C57BL/6J ±  kb
transcript OTTMUST00000062678 VEGA | MGI Sequence Detail 4056 Not Applicable 
polypeptide OTTMUSP00000030940 VEGA | MGI Sequence Detail 1168 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009656 laminin subunit beta-3
References
(Earliest) J:13948 Karn RC, Tcp changed to Abp. Mouse News Lett. 1983;69:25
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(61)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16713

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory