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Lamc1
Gene Detail
Symbol

Name
ID
Lamc1
laminin, gamma 1
MGI:99914
Synonyms
Lamb2, laminin B2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr1:153218922-153332786 bp, - strand
From VEGA annotation of GRCm38

  113865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMC1
Gene Tree: Lamc1

Human
homologs
LAMC1, laminin, gamma 1 (formerly LAMB2)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3915
neXtProt AC: NX_P11047

Human Synonyms: LAMB2

Human Chr (Location): 1q31; chr1:183023460-183145592 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Gene trapped(74) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation lack development of basement membranes, migration of primitive endoderm cells out of the inner cell mass, and parietal yolk sac development, resulting in lethality by embryonic day 5.5.
 
Interactions
Lamc1 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell adhesion, cell migration, ...
Component basal lamina, basement membrane, ...
Function extracellular matrix structural constituent, glycosphingolipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (343)    Tissues (249)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 86
RNA in situ 222
Northern blot 20
RT-PCR 15
cDNA source data(229)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamc1 ; ZFIN lamc1    NEW 
Molecular
reagents
All nucleic(234) Genomic(1) cDNA(229) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030992 (Evidence)
Ensembl Gene Model ENSMUSG00000026478 (Evidence)
Entrez Gene 226519 (Evidence)
UniGene 1249
DFCI TC1572404
DoTS DT.493450, DT.94405048
NIA Mouse Gene Index U021900
PDB 1KLO, 1NPE, 1TLE, 4AQT
Consensus CDS Project CCDS15370.1
International Mouse Phenotyping Consortium Status Lamc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030992 VEGA Gene Model | MGI Sequence Detail 113865 C57BL/6J ±  kb
transcript OTTMUST00000076764 VEGA | MGI Sequence Detail 7622 Not Applicable 
polypeptide OTTMUSP00000040460 VEGA | MGI Sequence Detail 1607 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(6) : SNPs within 2kb(1251 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1257)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009658 laminin subunit gamma-1
References
(Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:210260 Yao Y, et al., Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun. 2014;5:3413
All references(178)
Other
accession IDs
MGD-MRK-16712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory