Lamc1
Gene Detail

Symbol Name ID

Lamc1 laminin, gamma 1 MGI:99914

Synonyms

Lamb2, laminin B2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr1:153218922-153332786 bp, - strand From VEGA annotation of GRCm38   113865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamc1

Human homologs

Human Homolog		LAMC1, laminin, gamma 1 (formerly LAMB2)
NCBI Gene ID		3915
neXtProt AC		NX_P11047
Human Synonyms		LAMB2
Human Chr (Location)		1q31; chr1:182992595-183114727 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(79) : Targeted(5) Gene trapped(74)
 

Embryos homozygous for a targeted null mutation lack development of basement membranes, migration of primitive endoderm cells out of the inner cell mass, and parietal yolk sac development, resulting in lethality by embryonic day 5.5.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell adhesion, cell migration, ...
Component	basal lamina, basement membrane, ...
Function	extracellular matrix structural constituent, glycosphingolipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (86 records)
Data Summary: Results (238)    Tissues (193)    Images (44)
Theiler Stages: 1, 2, 3, 4, 7, 11, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	172
Northern blot	23
RT-PCR	20

cDNA source data(229)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(233) Genomic(1) cDNA(229) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030992 (Evidence)
Ensembl Gene Model	ENSMUSG00000026478 (Evidence)
Entrez Gene	226519 (Evidence)
UniGene	1249
DFCI	TC1572404
DoTS	DT.493450, DT.94405048
NIA Mouse Gene Index	U021900
PDB	1KLO, 1NPE, 1TLE, 4AQT
Consensus CDS Project	CCDS15370.1
International Mouse Knockout Project Status	Lamc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030992	VEGA Gene Model | MGI Sequence Detail	113865	C57BL/6J
transcript	OTTMUST00000076764	VEGA | MGI Sequence Detail	7622	Not Applicable
polypeptide	OTTMUSP00000040460	VEGA | MGI Sequence Detail	1607	Not Applicable

All sequences(52) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(6) : SNPs(943 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009658	laminin subunit gamma-1

References

(Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:192457 Santos TG, et al., Laminin-gamma1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons. J Neurochem. 2013 Jan;124(2):210-23
All references(170)

Other accession IDs

MGD-MRK-16712