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Lamc1
Gene Detail
Symbol

Name
ID
Lamc1
laminin, gamma 1
MGI:99914
Synonyms
Lamb2, laminin B2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr1:153218922-153332786 bp, - strand
From VEGA annotation of GRCm38

  113865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lamc1

Human
homologs
Human Homolog LAMC1, laminin, gamma 1 (formerly LAMB2)
NCBI Gene ID 3915
neXtProt AC  NX_P11047
Human Synonyms  LAMB2
Human Chr (Location)  1q31; chr1:183023460-183145592 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Gene trapped(74) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation lack development of basement membranes, migration of primitive endoderm cells out of the inner cell mass, and parietal yolk sac development, resulting in lethality by embryonic day 5.5.
 
Interactions
Lamc1 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell adhesion, cell migration, ...
Component basal lamina, basement membrane, ...
Function extracellular matrix structural constituent, glycosphingolipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (89 records)
Data Summary: Results (341)    Tissues (249)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 86
RNA in situ 222
Northern blot 20
RT-PCR 13
cDNA source data(229)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(233) Genomic(1) cDNA(229) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030992 (Evidence)
Ensembl Gene ModelENSMUSG00000026478 (Evidence)
Entrez Gene226519 (Evidence)
UniGene1249
DFCITC1572404
DoTSDT.493450, DT.94405048
NIA Mouse Gene IndexU021900
PDB1KLO, 1NPE, 1TLE, 4AQT
Consensus CDS ProjectCCDS15370.1
International Mouse Knockout Project StatusLamc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030992 VEGA Gene Model | MGI Sequence Detail 113865 C57BL/6J ±  kb
transcript OTTMUST00000076764 VEGA | MGI Sequence Detail 7622 Not Applicable 
polypeptide OTTMUSP00000040460 VEGA | MGI Sequence Detail 1607 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(6) : SNPs within 2kb(1251 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1257)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009658 laminin subunit gamma-1
References
(Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:210260 Yao Y, et al., Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun. 2014;5:3413
All references(178)
Other
accession IDs
MGD-MRK-16712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory